calcium d glucarate

Calcium D-Glucarate

Today, you still hear ongoing debates about the need to detox. The body naturally detoxifies itself, so we should be fine, right? Yes and no. The body does naturally detoxify, but we may need to assist it in that process due to the amount of toxins we face daily. And there is one supplement in particular that can help with this process, Calcium D-Glucarate, which is the focus on our article today.

One of the main process that the body uses for detoxing itself is called conjugation - - literally combining toxins with other substances to neutralize them or prepare them for elimination. For example, one form of conjugation is the combining of glucoronic acid with carcinogens such as synthetic estrogens. It is a process called glucuronidation whereby toxins are literally "washed" from the body. It enables the body to rid itself of foreign elements including xenoestrogens, pollutants, toxins, and carcinogens.

Glucuronidation is literally a process in which glucuronic acid is conjugated (joined) to various toxins in the liver so that they can be excreted through the bile or urine. It represents one of the major pathways for the body to rid itself of foreign substances and is responsible for removing a number of highly toxic chemicals from our system, such as polycyclic aromatic hydrocarbons, steroid hormones, nitrosamines, heterocyclic amines, aromatic amines, and fungal toxins. It also removes "used" hormones and synthetic hormones from the body.

Glucuronidation, then, represents a major means of converting most drugs, steroids, and many toxic and "environmental" substances to metabolites that can be excreted into the urine or bile. The bottom line is that glucuronidation is one of the main ways the body purges itself of carcinogenic substances. In times past, glucuronidation was sufficient to protect us from cancer. Two things have changed in the last hundred years that contribute significantly to the increase in the incidence of cancer we now see.

  1. We are exposed to far more carcinogens in our food supply, water, and air than ever before. (For example, there are over 2,000 known carcinogens just in the average drinking water in the United States today.)
  2. Thanks to changes in diet and the overuse of antibiotics in medicine and our food supply, the levels of the enzyme called beta-glucuronidase are much much higher in our bodies than ever before.

Beta-glucuronidase is an enzyme produced by E. Coli bacteria in the gut. Glucuronidase literally breaks the bond between the toxic compounds the body is trying to eliminate and the glucuronic acid that is responsible for eliminating them. When beta-glucuronidase breaks the bond, the hormone or toxin is once again released into the body instead of being excreted. Elevated glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast, prostate, and colon cancers.

Can we reduce our exposure to beta glucuronidase? Absolutely.

Taking probiotic supplements can dramatically reduce the number of beta-glucuronidase-producing bacteria in the gut. A diet that reduces red meat to less than 3 ounces a day and emphasizes plenty of vegetables and fruits, whole grains, and fermented foods containing live organisms also promotes a healthy population of friendly bacteria and a significant reduction in E. Coli populations.

Calcium D-Glucarate

And there is another way. Calcium D-Glucarate (a calcium salt found in foods such as apples, grapefruit, broccoli, Brussels sprouts, cabbage, lettuce, and alfalfa) suppresses beta-glucuronidase and restores the glucuronidation detoxification pathway. The beauty of Calcium D-Glucarate is that not only does it neutralize the effects of beta-glucuronidase, but it actually strengthens the bond between glucuronic acid and the cancer-causing toxins that are being flushed from the body.

Since the activity of glucuronidase is inhibited when we supplement with D-Glucarate, the body is better able to get rid of the various toxic chemicals and excess hormones that might stimulate tumor formation.

Studies in animals have shown that supplementing with D-Glucarate blocked tumor formation in over 70% of the animals tested, and this has been confirmed in studies with human tumor cells. The bottom line is that D-Glucarate lowers the level of glucuronidase, and in so doing allows the body to eliminate harmful carcinogens thereby stopping many tumors, including those of the colon, lungs, liver, breast, skin, and prostate from ever forming. In addition, studies have shown that D-Glucarate can actually shrink those tumors even if they are already well developed.

By supplementing the diet with D-Glucarate, we can block glucuronidase activity, and the body can rid itself of carcinogens, thus inhibiting the onset of many forms of cancer, including lung, breast, prostate, and colon.

Since the effect of a single low dose can last for hours, manufacturers recommend a daily intake of 400 to 600 mg of D-Glucarate split between two doses, morning and evening. Higher amounts (1,000 to 2,000 mg per day) are typically recommended for individuals with existing cancer. (Note: D-Glucarate is widely available in health food stores and over the internet.)

And remember. Supplementing with D-Glucarate is not a magic bullet. It is merely a piece of the puzzle. It is vital that you rebuild the beneficial bacteria in your colon through dietary changes, colon cleansing and detoxification, and supplementation with a good probiotic, thereby reducing the amount of beta-glucuronidase in your intestinal tract.

Probiotics from Baseline Nutritionals

Learn more about liver detox and colon detox benefits.



    Submitted by cis on
    November 23, 2014 - 5:23am
    Nottingham, UK ,

    Yes but is CDG safe to take for those of us who have far too many "silver fillings"? I tend to get this feeling of muscle "cramp/spasm" (leg heaviness, like lactic acid) or muscle fasciculations (bunches of muscle fibres contracting then releasing etc at random).

    Also, my muscles feel "tired" (like DOMS) during the warmup. Very weird feeling. My DOMS feels more like having a cold/flu.

    Heavy metal load may cause muscle cramps but then some people have reported experiencing muscle spasms when taking CDG. How can I work out which it is?

    Submitted by BaselineFoundation on
    November 26, 2014 - 5:26pm

    Have you ever tried a good heavy metal detox?

    Submitted by Martha Ray on
    February 7, 2018 - 4:23pm
    Charlottesville , Virginia

    I wish I knew the answer to you question. CDG gave me leg cramps at first but I have wanted to take it for many many years so I tried it again with meals and have not had any leg and foot cramps. To the best of my knowledge I no longer have any amalgam in my mouth but had many and all of those were replaced 'conventionally' over years. I may have deposits of mercury but dental test (Dr. Blanche Grube did) and a Doctors Data hair test did not show high. Regular calcium I'd taken began causing me cramps and also all forms of magnesium except for the new Threonate form did as well. I thought that was strange but I've not found any of my doctors that can answer that and two other rather odd supplement side effects I have had... melatonin all forms all doses causes almost immediate eye pain and Vit C causes me slight bowel bleeding even in small doses if taken consistently. Don't think those are related to each other of the calcium cramps but I sure do miss those two supplement. BTW I am taking CDG for very high Beta-Glucuronidase from GI Effects test. Did you ever determine any thing about CDG cramping side effect?

    Submitted by Charles Martel on
    July 18, 2018 - 3:08am

    EDTA and DMSA chelation, try both, may help with your eye problem after melatonin and after having so many fillings. I also recommend several good mold/fungal toxin binder like glucomannan and activated charcoal. Went through all this myself.

    Submitted by BaselineFoundation on
    July 30, 2018 - 1:58pm
    Submitted by KT on
    August 20, 2018 - 5:18pm
    USA , New York

    I see a lot of articles recommending Calcium D-Glucarate. However please be careful trying this supplement, not everyone responds the same way. I often have "paradoxical" reactions to medications and supplements. Calcium D-Glucarate caused sudden and huge weight gain, hormonal imbalance, water retention, acne, PMS all the time, delayed periods, sore boobs, weird mood swings from depression to anxiety, and much more, I'd never experienced anything like it. Horrible.

    I stayed on Calcium D-Glucarate for a nightmare 4 months because my Doc insisted it would help with my auto-immune illness, and detoxing from long-term antibiotic therapy.

    When I threw in the towel and stopped taking Calcium D-Glucarate, the withdrawal was worse than anything I've ever experienced too. Depression, weeping, anxiety, paranoia, panic, angry outbursts, all very abnormal for my usually happy and steady personality. It was a truly terrifying experience. I nearly admitted myself to a psych ward for the night at one point.

    Submitted by Fleur on
    October 23, 2018 - 7:57pm
    Nsw ,

    Hi there, this is concerning! Was your cdg mixed with anything? And what was your dosage? I’ve just started on it after DIM causes massive fluid retention (which is what I’m trying to treat)

    Submitted by June on
    January 11, 2019 - 12:43pm

    This is bizarre. I also had adverse effects to both DIM and calcium d glucarate. DIM caused headaches that lasted for days even after stopping the dose. 100mg of Calcium d glucarate caused major exhaustion and anxiety. So exhausted I would have anxiety/heart palpitations. This makes me wonder if it affects my thyroid or adrenals. Its been 2 days since that dose and I am still recovering from it.

    Submitted by Mary on
    March 31, 2019 - 10:03pm

    I started calcium d-glucarate one month ago and have had sudden weight gain in the same month (especially in my belly). I don't know if the supplement caused the weight gain. Can you tell me more about your experience with calcium d-glucarate causing weight gain? Did the weight go back go normal when you stopped taking it? Thank you, and i hope you are well.

    Submitted by Michele on
    April 8, 2019 - 1:04pm
    Chicago , Illinois

    I have maintained my desired weight for about 6 years, then added calcium d-glucarate for about 6 weeks, and during that time, experienced significant abdominal fat gain. Has this happened to anyone else, and can anyone provide reassurance that the abdominal fat will disappear again after stopping the supplement?

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