Cetyl Myristoleate

Cetyl Myristoleate

Arthritis Pain Relief

Cetyl myristoleate (CMO) is the common name for cis-9-cetyl myristoleate, a relative of the Omega-9 fatty acid found in olive oil. It is a completely natural medium chain fatty acid found in certain animals, including cows, whales, beavers, and mice -- but not in people. It has multiple biological properties, including as an anti-inflammatory and a pain reliever, as well as being an immune system modulator.

CMO was discovered in 1972 by Harry W. Diehl, Ph.D., a researcher at the National Institutes of Health. At the time, Dr. Diehl was responsible for testing anti-inflammatory drugs on lab animals. In order for him to test the drugs, he first had to artificially induce arthritis in the animals by injecting a heat-killed bacterium called Freund's adjuvant health supplement. Dr. Diehl discovered that Swiss albino mice did not get arthritis after injection of Freund's adjuvant health supplement.

Eventually, he was able to determine that cetyl myristoleate was the factor present naturally in mice that was responsible for this protection. When CMO was injected into various strains of rats, it offered the same protection against arthritis.  In fact, there have been three notable studies on humans.

The first double-blind study was conducted in 1997 under the auspices of the Joint European Hospital Studies Program. Of the 106 people who received cetyl myristoleate, 63% showed improvement VS just 15% for the 226 people in the placebo group.

In 2001, a study of 1814 arthritis patients found that over 87% of the subjects in the study had greater than 50% arthritis pain relief and recovery and over 65% of those showed from 75% - 100% recovery following a sixteen-day regimen. All types of arthritis were positively affected by CMO. Only those subjects with liver damage or digestive problems or those taking immune suppressing medications were not helped.

In 2002, a double-blind study of 64 people with chronic knee pain, published in the Journal of Rheumatology, concluded that CMO provided a significant functional improvement in range of motion VS placebo. In fact, the study concluded that CMO "may be an alternative to the use of nonsteroidal anti-inflammatory drugs for the treatment of osteoarthritis."

Cetyl-M is great for arthritis pain relief and is available in capsules, tablets, lotions and creams. For a natural food alternative, nuts containing palmitic acid, such as the nuts from palm and coconut trees, may be a good choice. However, in order to get the most out of CMO, it is best to avoid foods or substances that may interfere with its absorption such as caffeine, chocolate, alcohol, and nicotine.

For more information on chronic joint pain and inflammation, check out Jon Barron's article called "A Five-Pronged Approach to Chronic Joint Pain and Inflammation." and read more of our anti-aging articles.



    Submitted by Andi Bayer on
    August 29, 2013 - 12:53am

    Do you have further information concerning this topic? I am interested in why the test subjects that had liver damage did not benefit from CMO.

    Submitted by BaselineFoundation on
    August 30, 2013 - 3:31am

    All fatty acids enter systemic circulation through the liver. An oil like cetyl myristoleate would begin its systemic circulation from the liver also, but if the liver is damaged, it would not be able to do that efficiently.

    Submitted by Maple on
    July 21, 2014 - 3:12am

    Someone necessarily lend a hand to make seriously posts I'd state. This is the very first time I frequented your website page and am surprised with the research you made to create this. Magnificent task!

    Submitted by Kathy on
    July 27, 2014 - 12:41am

    Good day I am so happy I found your blog, I really found you by accident. Please do keep up the excellent work.

    Submitted by Nessy on
    May 23, 2016 - 6:23pm
    Bay Area , California

    What is a reliable brand of CMO available to purchase?

    Submitted by BaselineFoundation on
    May 24, 2016 - 2:59pm

    The best natural products are usually formulas where you combine specific ingredients to enhance the others--just like nature. Jon Barron uses this ingredient in his Triple Jointed formula, see link at the end of the article, or go to: http://www.baselinenutritionals.com/products/triple-jointed.php

    Submitted by Mary on
    March 14, 2017 - 8:05pm
    Puerto Vallarta Mexico ,

    While your product does look interesting, I would be VERY concerned about taking 3 capsules on an empty stomach. I doubt it would be pleasant for me.

    Plus the cost of a 30 day supply is close to what I spend on food for a month. WOW! Not a very good choice.

    Submitted by BaselineFoundation on
    March 15, 2017 - 1:26pm

    The Baseline of Health Foundation doesn’t actually make or sell any products. We assume you’re talking about Baseline Nutritionals’ Triple Jointed formula. 

    For those who have chronic pain and have used the formula—some continuously for the last 12 years—it would appear that they consider it a VERY good choice, and obviously have NO problem taking it on an empty stomach. Then again, as the instructions say, it can also be taken with food. As for cost, the question is: what is getting rid of chronic pain worth? Also, if you buy three bottles at a time, it’s 20% off retail, and the product is also available several times a year as part of member specials for up to 40% off. If that matches your monthly food bill, that would be very impressive at only $54 a month.

    Submitted by Francis Moore on
    June 9, 2016 - 2:39pm
    Laguna Hills , California

    I've been told that mixing liquid CMO with DMSO had a 70 to 30% ratio and then applied topically helps joint pain as well. Are there other people who have heard the same thing?

    DMSO acts as a carrier through the skin and directly into the joint.

    Another question, how does CMO taken orally survive the stomach acid?

    Submitted by nicole on
    July 25, 2016 - 11:01am

    ^^ Yes, I would love to hear the answer to this question above. I have the DSMO and I also have the CMC in oil capsules and also in powder capsules. Which one would I use with the DSMO for best absorption?

    Submitted by Francis Moore on
    June 9, 2016 - 2:50pm
    Laguna Hills , California

    I want to thank you for this blog as well and I hope I will get regular reminders get other experiences with CMO in combination with DMSO.

    Submitted by Marianne on
    January 14, 2017 - 5:09pm
    Astoria , New York

    Does this really work?
    I am tired of chasing down pain relievers for my arthritic knees!!!

    Submitted by Clara Vivaldi on
    September 10, 2018 - 8:25pm
    Toronto - Canada ,

    I would like to read the article by Jon Barron: "A five pronged approach to chronic joint pain and inflammation" but it looks like it is not available. I would greatly appreciate your help. Thank you. Clara

    Submitted by BaselineFoundation on
    September 11, 2018 - 12:44pm
    Submitted by steve allen on
    March 20, 2019 - 5:54am
    Castle Douglas.Sotland.UK> ,

    the esterified fatty acid is myristoleic acid which is an omega-5 fatty acid of 14 carbons -oleic acid has 18 carbons and is omega-9 .Cetyle myristoleate is found in humans in adipose tissue .

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