Recently, we discussed herbal blood cleansers and how they work to boost the lymphatic system and actively defend against multiple kinds of cancer in the body. In that article, we mentioned that systemic, proteolytic enzymes also work to clean out the blood, but through entirely different pathways and mechanisms…and to entirely different end results. Although they may have some cancer protective benefits–and there are indeed cancer therapies based on proteolytic enzymes, not to mention a number of studies that support those therapies–the primary benefits we’re looking for when taking systemic, proteolytic enzymes center around their ability to:
- Control inflammation throughout the body, not just in your joints.
- Repair and rebuild the cardiovascular system.
- Optimize blood flow.
- Prevent and dissolve blood clots.
- Dissolve plaque in your arteries and dental plaque in your mouth.
- Clean up your immune system.
- Minimize the impact of allergies.
- Improve the ability to exercise and speed up recovery times.
And all of these benefits stem from one simple ability: proteolytic enzymes facilitate the breakdown of rogue proteins in your bloodstream and in the soft tissues of your body.
In this report, we’re going to take a look at exactly what systemic, proteolytic enzymes are, what they do, how they do it, and what the ideal proteolytic formula looks like.
What are enzymes?
In our previous report, Enzymes Defined, we explored the general nature of enzymes–what they are and what they do. In summary, enzymes are proteins that speed up chemical reactions. There are estimated to be between 50,000 and 70,000 different enzymes in your body that regulate every metabolic function in your body. Without enzymes, all of these metabolic functions would progress through the same steps, but would go too slowly to sustain life. In essence, enzymes make life happen where otherwise there would be none.
Most people, when they think of enzymes, think of digestive enzymes, and in the world of alternative health, that usually means digestive enzyme supplements. But as we’ve already mentioned, there are tens of thousands of different enzymes in the human body, and 99.999% have nothing to do with digestion.
Beyond Digestion
An important concept to understand is that digestive enzyme formulas and systemic/metabolic, proteolytic enzyme formulas, although they may share many of the same enzymes (protease, papain, bromelain, etc.), are not the same thing.
- When you take a digestive enzyme formula with your meal, the enzymes work on speeding up the breakdown of the food in your stomach.
- When you take a proteolytic enzyme formula between meals, the enzymes do not get stuck working in your stomach or wrapped up with your food and passed out through the colon. Instead, they quickly enter your bloodstream. Once in the bloodstream, they help optimize your blood, plus they make their way to all of the tissues throughout your body, where they assist with intelligent, adaptive healing.
Understanding Proteolytic Enzymes
The vast majority of metabolic enzymes in your body, the enzymes that regulate everything from liver function to the immune system, are proteases, or proteolytic enzymes. Proteolytic is a catchall phrase for hydrolytic enzymes that specifically facilitate the chemical breakdown of proteins by severing the bonds between the amino acids that make up those proteins.
Proteolytic enzymes occur naturally in all organisms and constitute 1-5% of all genetic content. They are different from other enzymes in the body in that they are able to adapt to changing needs. For example, the same proteolytic enzyme can meet both digestive and metabolic needs in the body. This is the reason that you will see some of the same proteolytic enzymes in both digestive enzyme formulas and systemic metabolic formulas.
The bottom line is that a healthy supply of these protein specific enzymes is essential for sustaining and maintaining optimal health.
Types of Proteolytic Enzymes
There are six classifications or groups of proteases in the human body:
- Serine protease
- Threonine protease
- Cysteine protease
- Aspartate protease
- Glutamic acid protease
- Metalloproteases
Most of the proteases that we’re going to talk about in this report are serine proteases. Serine proteases are enzymes that break peptide bonds in those proteins in which the amino acid serine plays a key role at the enzyme’s active site.1 Hedstrom, L. (Dec 2002). “Serine protease mechanism and specificity.” Chem Rev 102 (12): 4501–24. http://www.ncbi.nlm.nih.gov/pubmed/12475199 In humans, serine proteases are responsible for coordinating various physiological functions including digestion, immune response, blood coagulation, inflammation, and reproduction. Equally important, serine proteases are widely distributed in nature and found in all kingdoms of cellular life as well as many viral genomes. The ability to break down serine protein bonds in invading viruses carries some obvious advantages when it comes to defending your body.
The two exceptions that commonly figure in supplemental enzyme formulas are bromelain and papain, which are cysteine proteases. In humans, cysteine proteases are responsible for cell aging and cell death, and certain immune responses.2 Chapman HA, Riese RJ, Shi GP (1997). “Emerging roles for cysteine proteases in human biology.” Annu. Rev. Physiol. 59: 63–88. http://www.ncbi.nlm.nih.gov/pubmed/9074757 Thus, enzymes that regulate and enhance those reactions provide a perfect complement in any systemic, proteolytic enzyme formula. In addition, cysteine proteases play a role in bringing macrophages back into line when they are misprogrammed and attacking collagen and elastin at sites of inflammation such as arterial walls in atherosclerosis and lung tissue in emphysema.
Which leads us to the next piece of the puzzle.
Proteolytic Enzymes and Illness
Just about everything that makes us sick is either a protein or is protected by a protein and is therefore subject to control by proteolytic enzymes. For example:
Your DNA stores the code for all of your body’s proteins and enzymes. In essence, your DNA is a protein manufacturing plant. Genetic diseases are the result of your DNA no longer producing those proteins and enzymes accurately or doing it insufficiently or excessively.- Bacteria, viruses, yeasts, and fungi are all protected by proteins. Attacking those proteins is key to destroying the invaders.
- Food allergens are almost all proteins.
- Cancer cells are protected by proteins.
Proteolytic enzymes have the ability to digest and destroy the protein based defense shield of each and every pathogen, allergen, and rogue cell, thereby leading to their ultimate elimination. In addition, established cancers reprogram the production of enzymes in the body to both accelerate their own growth and protect themselves from the immune system. Supplemental proteolytic enzymes have the ability to alter that dynamic.
And then there are CIC’s (Circulating Immune Complexes). CIC’s start out as extra-large protein molecules (primarily from wheat, corn, dairy, and soy) that are only partially digested in the small intestine and are absorbed into the bloodstream. Once in the bloodstream, the immune system treats them as invaders because they are too large to be metabolized, provoking an immune reaction. Antibodies couple with these foreign protein invaders to form CIC’s. At first, these CIC’s may be neutralized by the immune system, then eliminated through the lymphatic system and the kidneys. But over time, as too many CIC’s are created, they overwhelm the body’s ability to eliminate them. At that point, the body has no choice but to “store” them in its own soft tissues, where the immune system continues to attack them as allergens, which leads to inflammation3 Arazi A1, Neumann AU. “Modeling immune complex-mediated autoimmune inflammation.” J Theor Biol. 2010 Dec 7;267(3):426-36. http://www.ncbi.nlm.nih.gov/pubmed/20832412 and, ultimately, autoimmune disorders such as lupus.4 P O Cano, L M Jerry, J P Sladowski, and C K Osterland. “Circulating immune complexes in systemic lupus erythematosus.” Clin Exp Immunol. Aug 1977; 29(2): 197–204. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541106/pdf/clinexpimmunol00234-0013.pdf In fact, studies have shown that diseases that present high CIC-levels can be improved or even cured by eliminating excess CICs.5 Stauder G, Ransberger K, Streichhan P, Van Schaik W, Pollinger W. “The use of hydrolytic enzymes as adjuvant therapy in AIDS/ARC/LAS patients.” Biomed Pharmacother. 1988;42(1):31-4. http://www.ncbi.nlm.nih.gov/pubmed/3408806
It is here that proteolytic enzyme supplements come into play. They compensate for your dietary inadequacies and errors by making their way into your bloodstream, where they set to work breaking down CIC’s in your blood and soft tissues — eventually passing the waste out through your kidneys and lymphatic system.
And finally, some proteolytic enzymes such as nattokinase and seaprose-S are very specialized. They work on specific protein related tasks such as optimizing blood, reducing pain and inflammation, and cleaning out the lungs. (We’ll talk more about those later.)
Why You Need to Supplement?
In a perfect world, we would all eat raw (organic) unprocessed foods that are naturally high in active enzymes.
But this isn’t a perfect world.
Most people eat food that is enzyme deficient (cooking and processing destroy enzymes) and fail to chew food adequately (saliva contains amylase) so their bodies must compensate. The body is forced to divert its production of metabolic proteolytic enzymes into the production of large amounts of pancreatic enzymes in order to break down all of the dead food in our diets. Short term, this is not a problem. Your body can easily handle it. But the long-term consequences of this diversion are enormous. It can lead to everything from a weakened immune system to thickened blood, from pain and inflammation to cardiovascular disease, and from reduced athletic performance to difficulty breathing. Supplementing with proteolytic enzymes offsets this devastating diversion and restores balance.
Absorbing Proteolytic Enzymes
Many so called experts say that you can’t absorb proteolytic enzymes. First, they claim that as proteins, they are broken down by stomach acid unless they are in enterically coated capsules. Then, other “experts” say that even if they do survive the stomach, their molecules are too big to pass through the walls of the small intestine–so you can’t absorb them anyway. Whenever I hear these arguments, I’m reminded of the apocryphal story of the engineer who proved that bumblebees can’t fly.6 Cecil Adams. “Is it aerodynamically impossible for bumblebees to fly?” The Straight Dope. May 4, 1990. (Accessed 24 Jun 2014.) http://www.straightdope.com/columns/read/1076/is-it-aerodynamically-impossible-for-bumblebees-to-fly Applying the principles of aerodynamics, he PROVED, based on their size, weight, the surface area of their wings, and the physiological limits of how fast they could flap them, that bumblebees could not fly. Of course, as we all know, bumblebees can indeed fly. The so-called proof is humorous nonsense.
The absorption of proteolytic enzymes is a lot like that. It really doesn’t matter how many theories you come up with to explain why they can’t be absorbed; in the end, you can both measure their presence in the bloodstream and, more importantly, quantify the results of supplementation in your own body.
In any case, let’s deal with the stomach acid issue first. There are two rebuttals:
- I dealt with this issue in detail in the Enzymes Defined newsletter. In summary, pepsin (which is produced in the stomach), amylase (which is found in saliva), and lactase (which is added to dairy products) are three examples of enzymes that not only survive in high acid environments but actually thrive there. Yes, there are some animal based proteases (serrapeptase from silkworms, for example) that can’t handle acid very well and need to be enterically coated; but for the most part, enzymes, even though they are proteins, are too big and too complex to be unfolded by the acid in the stomach, which means they can’t be digested. Most are merely rendered temporarily inactive by the high acid environment…and then reactivated the moment they enter the more alkaline environment of the intestinal tract.
- And even if all systemic proteolytic enzymes were destroyed by digestive juices, instructions for using most such formulas tell you to take them between meals — when stomach acid levels are extremely low. Thus, the issue is moot…at least for a well-designed formula, used properly.
When I designed my own proteolytic enzyme formula, I specifically selected enzymes that survive the stomach acid environment. It’s actually not that hard to do. The key is to use non-animal derived enzymes. As a rule, fungal and plant-based enzymes easily survive stomach acid. Oral supplementation with non-animal derived enzymes, such as microbial or fungal enzymes — those manufactured by a fermentation process of Aspergillus, for example–possess unusually high stability and activity throughout a wide range of pH conditions (from a pH of 2-10).7 Brad Rachman, “Unique Features and Application of Non-Animal Derived Enzymes.” Clinical Nutrition Insights. 510 8/97 Vol. 5, No. 10. (Accessed 24 Jun 2014.) http://acudoc.com/Digestive%20Enzymes.PDF This not only guarantees their survival in the stomach but enables them to be more consistently active and functional as they are transported through the digestive tract. There have been studies that have specifically verified that plant-based proteolytic enzymes such as bromelain easily survive passage through the stomach.8 Laura P. Hale. “Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.” International Immunopharmacology. Volume 4, Issue 2, February 2004, Pages 255–264. http://www.sciencedirect.com/science/article/pii/S1567576903002972 Bottom line: most supplemental proteolytic enzymes are not destroyed by stomach acid.
Now let’s address the issue of absorption. The standard medical assumption–and it was taught in medical school for years–is that no dietary protein is absorbed in an undigested form — pretty much without exception. Rather, since their molecules are too large, dietary proteins must first be digested into amino acids or di- and tripeptides before they can be absorbed. At first blush, that seems to exclude undigested enzymes, which are indeed proteins–and extremely large ones at that. But study after study proves that supplemental enzymes do indeed cross the intestinal wall and enter the bloodstream. Although the definitive answer as to how they accomplish this is unknown at this time, studies suggest that proteolytic enzymes are able to increase the permeability of the mucosal epithelium and, hence, facilitate their own absorption by a mechanism of self-enhanced paracellular diffusion.9 KOLAC C., STREICHHAN P., LEHR C.-M. “Oral bioavailability of proteolytic enzymes.” European journal of pharmaceutics and biopharmaceutics. 1996, vol. 42, no4, pp. 222-232 (68 ref.) http://cat.inist.fr/?aModele=afficheN&cpsidt=3191444 Or to translate that for the layperson: unlike food proteins that must be absorbed into the cells that line the small intestine, enzymes pass between those same cells–and thus can pass whole, without being broken down into their constituent peptides and amino acids.
When summarizing the arguments pro and con on the absorption of non-enterically coated proteolytic enzymes in the intestinal tract, I’m reminded of the movie Chicago. The husband of Kitty (Lucy Liu) says to his wife when she catches him in bed with two women, “Come on, darling, you gonna believe what you see or what l tell you?” The correct answer is obvious, so she shoots him. In the end, it doesn’t matter what some experts say, proteolytic enzyme supplements can be measured in the bloodstream…and their benefits can be seen by anyone who uses them.
A Proteolytic Enzyme Absorption Challenge
Several years ago, I issued a challenge to readers to validate the ability of the non-enterically coated, systemic, proteolytic enzyme formula that I had created to dissolve dental plaque. This is significant since, for this to happen, the enzymes have to pass through the stomach unscathed, be absorbed in the intestinal tract, make their way into the bloodstream, pass from there into your salivary glands, and then finally out into your mouth. If they can do that, that proves the case for absorption, in spades! Well, we heard from a number of our readers who took the challenge. The response below was typical.
“Five months ago I had my teeth cleaned. At that time I had the expected, usual amount of plaque on my teeth. So the hygienist cleaned it up. One month ago I began taking the Proteolytic Enzymes for some joint inflammation I was experiencing after taking a round of antibiotics for a strong kidney infection. With the help of the Proteolytics, the pain went away very quickly, as I thought it would. Then 2 days ago, I went to the dentist again to have my teeth cleaned and sealed. The hygienist said I did not need my teeth cleaned because there was no plaque on my teeth at all!” Caitlin W., OH
At this point, it’s probably worth just leaving the critics to argue amongst themselves with their bumblebee like arguments and examine what’s before our eyes. The bottom line is that in addition to the empirical evidence that proves that proteolytic enzymes consumed orally are absorbed and impact internal systems in the body, there are also a plethora of peer-reviewed studies. For example:
- There are now upwards of 80 studies that prove that nattokinase works, and that it works in vivo, which means that it passes through stomach acid unharmed, passes through the intestinal wall, and enters the bloodstream.10 http://www.ncbi.nlm.nih.gov/pubmed/?term=nattokinase
- As with nattokinase, bromelain is backed by upwards of 80 studies over the years that substantiate its efficacy in the treatment of inflammatory disorders of the musculoskeletal system.11 http://www.ncbi.nlm.nih.gov/pubmed/?term=bromelain+inflammation
- And combinations of hydrolytic enzymes have been used for the treatment of a variety of diseases for many years, including the treatment of inflammation, traumatological events, surgical interventions, autoimmune and immune complex diseases, rheumatological diseases, viral infections, and malignant tumors.12 Stauder G. “Pharmacological effects of oral enzyme combinations.” Cas Lek Cesk. 1995 Oct 4;134(19):620-4. http://www.ncbi.nlm.nih.gov/pubmed/7585874
Why We Supplement with Systemic Proteolytic Enzymes
In addition to directly breaking down problematic proteins such as the fibrin that both produces dangerous blood clots and holds arterial plaque together, proteolytic enzymes play a key role in modulating both the immune response and inflammatory cascades.
According to a study published in the Slovakian journal, Bratislavské Lekárske Listy, there is strong evidence that systemic enzyme therapy can improve the composition of blood and the properties of vessel walls, as well as both prevent and dissolve dangerous blood clots and the consequences of venous insufficiency.13 Nouza K. “Systemic enzyme therapy in diseases of the vascular system.” Bratisl Lek Listy. 1995 Oct;96(10):566-9. http://www.ncbi.nlm.nih.gov/pubmed/8620329 The study went on to say that the key feature of enzymotherapy appears to be its immunomodulatory activity. “There exists a strong evidence for the favorable modulation of pathogenic autoantibodies, inhibition of the neogenesis of immune complexes and cleavage of their deposits, [and] normalization of the T cell system, network of cytokines [i.e., rebalancing pro-inflammatory and anti-inflammatory cytokines], adhesion molecules and inflammatory cascades.” Or again, to put things in laymen’s terms: supplemental, proteolytic enzymes can shift your immune system away from an automatic, reactive response to a more measured, moderated response, calm down systemic inflammatory cascades, and, as already discussed, significantly reduce levels of circulating immune complexes, all of which can be extremely beneficial for anyone dealing with any autoimmune conditions such as rheumatoid arthritis–as well as anyone looking to avoid them.
Armed with an understanding of how your body utilizes proteolytic enzymes, it becomes clear that the advantages of supplementing with a good systemic, proteolytic enzyme formula are profound. Possible benefits include:
- Reduced systemic inflammation for: Increased heart health, cancer and disease prevention and recovery, Alzheimer’s prevention, fibromyalgia and chronic fatigue relief, and more.
- Cleanses the blood of debris.
- Breaking down and removes circulating immune complexes.
- Dissolving fibrin in the blood, reducing the risk of clots.
- Dissolving fibrin in arterial plaque, thus leading to the breakup of arterial plaque.
- Eliminating the risk of DVT (Deep Vein Thrombosis) when flying.
- Boosting the immune system.
- Killing bacteria, viruses, and other invading pathogens.
- Improved circulation.
- Eliminating CICs
- Eliminating autoimmune diseases.
- Reduced risk of and response to food and pollen allergies.
- Accelerated recovery from sprains, strains, fractures, bruises, contusions,
and surgery. - Faster recovery time from workouts.
- Help with MS.
- Help with arthritis.
- Eliminating plaque from teeth.
- Helping with sinusitis and asthma.
- Dissolving arterial scar tissue.
- Aiding in cleansing and detoxification.
- Improved body alkalinity.
- Reduced risk of osteoporosis.
Proteolytic Enzymes and Cancer
Systemic enzyme therapy has been subjected to experimental investigations and to rigorous clinical studies in cancer patients. The results of in vitro and in vivo investigations documented the immunological, anti-inflammatory, anti-infectious, and antitumor/antimetastatic activities of proteolytic enzyme mixtures (containing trypsin, chymotrypsin, and papain) or bromelain. EBM level II clinical studies, which are accepted by the European Union to show both the safety and efficacy of medical treatments, were also performed to evaluate the benefit of complementary systemic enzyme therapy in cancer patients suffering from breast and colorectal cancers and plasmacytoma. These studies demonstrated that systemic enzyme therapy significantly decreases tumor-induced and therapy-induced side effects and complaints such as nausea, gastrointestinal complaints, fatigue, weight loss, and restlessness and obviously stabilized the quality of life. For plasmacytoma patients, complementary systemic enzyme therapy was shown to increase the response rates, the duration of remissions, and the overall survival times.14 Beuth J. “Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction?” Integr Cancer Ther. 2008 Dec;7(4):311-6. doi: 10.1177/1534735408327251. http://www.ncbi.nlm.nih.gov/pubmed/19116226 Then again, this is hardly surprising, as previous studies have shown that the treatment of human white blood cells with proteolytic enzymes leads to the production of large amounts of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1 beta), and interleukin-6 (IL-6) in a time and dose dependent manner.15 Desser L, Rehberger A, Paukovits W. “Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro.” Cancer Biother 1994;9:253-63. http://www.ncbi.nlm.nih.gov/pubmed/7529614
What Constitutes a Good Systemic Proteolytic Enzyme Formula?
So what should you look for in a properly designed supplemental proteolytic enzyme formula?
- First, it needs a lot of protease. You want at least 200,000 HUT. This is far more than you will ever find in a digestive formula. 300,000 HUT is even better. And you will want to use vegetarian enzymes since they are much more tolerant of stomach acid and work in a much wider range of pH environments.
- Second, you also want a good variety of enzymes which utilize different biological pathways and whose benefits complement, rather than duplicate, each other.
- Third, there are some non-proteolytic enzyme ingredients that you will also want to include in the formula both because they increase the efficacy of the proteolytic enzymes in the formula and because they provide their own complementary benefits as well.
With that said, let’s now take a look at the ingredients that I include in what I consider the ideal systemic, proteolytic enzyme formula.
Fungal Protease and Fungal Pancreatin
Fungal protease and fungal pancreatin are names for particular strains of vegetarian protease enzymes. These are the general workhorses of the formula. In fact, pretty much the entire newsletter so far has been a discussion of the benefits associated with these enzymes.
Fungal pancreatin is a subset of fungal protease. It specifically refers to a mix of vegetarian sourced enzymes that mimics the enzymes produced by your pancreas. It is primarily a combination of trypsin, amylase, and lipase. The lipase and amylase are not proteolytic (i.e., they don’t work on proteins) but complement the action of proteolytics by working on leftover fats and carbohydrates both in the intestinal tract and the bloodstream–cleaning up what proteolytics cannot touch.
Keeping in mind that this formula is designed to be taken between meals, the amylase and lipase, which are frequently found in digestive enzyme formulas, are not included for the purpose of digesting food. In a systemic proteolytic formula, they, instead, play the role of garbage collectors. The addition of the amylase and lipase is important enough that I recommend augmenting the levels found in the fungal pancreatin with the inclusion of small amounts of pure amylase and lipase as part of the formula.
Bromelain and Papain — The Plant Enzymes
Bromelain actually refers to a mix of two similar enzymes, along with their related compounds, which are extracted from the stems of pineapples. Bromelain has been used by Europeans for many years to inhibit inflammatory factors. It has been suggested by some formulators that bromelain is destroyed by stomach acid and needs to be enterically coated to protect it. That’s simply not true. Consider that the pH of the stomach ranges from 3 or 4 during digestion (with only a quick burst to as low as 1 to 2 immediately after eating a high protein meal). But the stomach’s normal resting pH between meals is about 4 or 5. Now compare that to the pH of pineapple juice at 3.3-3.6 and you can see that bromelain is more than comfortable with the acid ranges found in the stomach–especially keeping in mind that systemic enzymes should be taken between meals, not with them.
Studies have shown that bromelain’s anti-inflammatory properties come from its ability to effectively inhibit neutrophil (immune cell) migration.16 Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. “Bromelain treatment decreases neutrophil migration to sites of inflammation.” Clin Immunol. 2008 Jul;128(1):66-74. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516972/ As such, it is not surprising that studies have shown that bromelain can be helpful in reducing swelling and speeding up the healing of surgical wounds,17 Tassman G, Zafran J, Zayon G. “A double-blind crossover study of a plant proteolytic enzyme in oral surgery.” J Dent Med 1965;20:51–4. http://www.ncbi.nlm.nih.gov/pubmed/14282458 as well as minor sprains, bruises, and sports’ injuries.18 Cirelli MG. “Treatment of inflammation and edema with bromelain.” Delaware Med J 1962;34:159–67. http://www.ncbi.nlm.nih.gov/pubmed/13879585 And bromelain has also been shown to be helpful in treating osteoarthritis.19 Brien S, Lewith G, Walker A, Hicks SM, Middleton D. “Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.” Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538506/ Note: studies show that its benefit in regard to osteoarthritis is amplified by the presence of rutin and trypsin–both of which are present in the formula we are now describing.20 Akhtar NM1, Naseer R, Farooqi AZ, Aziz W, Nazir M. “Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee–a double-blind prospective randomized study.” Clin Rheumatol. 2004 Oct;23(5):410-5. http://www.ncbi.nlm.nih.gov/pubmed/15278753
And if that’s not enough, research shows that bromelain may help support healthy blood viscosity and blood platelet aggregation,21 Heinicke R, van der Wal L, Yokoyama M. “Effect of bromelain (Ananase) on human platelet aggregation.” Experientia 1972;28:844–5. http://www.ncbi.nlm.nih.gov/pubmed/4658882 so it should not be surprising that studies show it’s also protective against heart attacks.22 Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, et al. “Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium.” Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581828/
Papain, which is an enzyme found in unripe papayas, has properties similar to bromelain. It is well known for its use as a meat tenderizer, since, as a natural proteolytic enzyme, it breaks down the proteins in meat–thus tenderizing it. This same ability means that we find papain used in many digestive enzyme formulations. But that’s not the reason we use it in a systemic enzyme formula–at least not directly. If papain is taken between meals, it makes its way into the bloodstream where it helps reduce pain and inflammation, as well as fluid retention following trauma and surgery. In fact, studies have shown that papain possesses strongly marked anti-inflammatory activity, and this ability is no less than that of the pharmaceutical drugs, butadion and indomethacin.23 Rakhimov MR. “Anti-inflammatory activity of domestic papain].” Eksp Klin Farmakol. 2001 Jul-Aug;64(4):48-9. http://www.ncbi.nlm.nih.gov/pubmed/11589110 Papain is also used for treating parasitic worms, shingles, and psoriasis, as well as being used along with conventional treatments for tumors.
Nattokinase
Nattokinase is extracted and purified from a traditional Japanese food called natto. Natto is made from boiled or steamed soybeans fermented with the beneficial bacteria, Bacillus subtilis natto.24 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. “Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan.” Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347. http://www.ncbi.nlm.nih.gov/pubmed/8280151 It is very important to understand that although nattokinase is extracted from natto, a soy based food, it is not natto itself, and it contains no soy. It is a purified enzyme that no longer has any soy characteristics left in it. Nattokinase has a remarkable ability to optimally balance the clotting ability of blood. It rivals pharmaceutical drugs such as warfarin in that ability but without any of the side effects or downsides, making it of value to everyone, not just heart disease patients. Obviously, if you are already using blood thinners, you will need to work with your doctor if you decide to incorporate a proteolytic enzyme formula in your health program–especially one containing nattokinase. Unfortunately, most doctors will opt to play it safe (for them, not you) and choose to keep you on the pharmaceuticals.
Studies have also shown that nattokinase works as an ACE inhibitor to help lower blood pressure.25 Murakami K1, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. “Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food.” Food Funct. 2012 Jun;3(6):674-8. http://www.ncbi.nlm.nih.gov/pubmed/22453301 In fact, a 2008 study conducted over eight weeks, found that nattokinase was able to moderately lower both systolic and diastolic blood pressure in hypertensive human subjects.26 Kim JY, Gum SN, Paik JK, et al. “Effects of nattokinase on blood pressure: a randomized, controlled trial.” Hypertens Res. 2008;31(8):1583-1588. http://www.ncbi.nlm.nih.gov/pubmed/18971533 And finally, a 2009 study out of Taiwan found that the nattokinase has the ability to dissolve amyloid fibrils, which means it may help prevent Alzheimer’s disease. Not a bad incidental benefit.
Seaprose-S
Seaprose-S is a semi-alkaline, serine, proteolytic enzyme produced by the fungus Aspergillus melleus. As reported in the journal Drugs under Experimental and Clinical Research, seaprose has both anti-inflammatory and anti-cold properties, demonstrating a potent ability to reduce painful inflammation and break up mucus. 27 Fossati A. “Anti-inflammatory effects of seaprose-S on various inflammation models.” Drugs Exp Clin Res. 1999;25(6):263-70. http://www.ncbi.nlm.nih.gov/pubmed/10713864 Specifically, this report pointed out that seaprose has shown anti-inflammatory activity against many different conditions, including arthritis, edema, pleurisy (inflammation of the lung lining), and peritonitis (inflammation of the lining of the abdomen). It also pointed out that in animal studies with arthritis, seaprose-S significantly reduced the primary and secondary lesions–demonstrating an ability to increase proteoglycan synthesis in cartilage.
Seaprose’s ability to break up mucus means it can offer relief for respiratory problems such as bronchitis, pulmonary tuberculosis, pulmonary emphysema, COPD, bronchiolitis, and bronchial asthma. Seaprose is so effective in this regard that it’s actually used as an ingredient in Japanese over-the-counter cold remedies. And in two other studies, researchers found that patients who used seaprose showed significant improvements in bronchial inflammation and in the viscosity of their mucus. In other words, it made the mucus thinner so that it cleared the lungs more easily.28 Moretti M, Bertoli E, Bulgarelli S, Testoni C, et al. “Effects of seaprose on sputum biochemical components in chronic bronchitic patients: a double-blind study vs placebo.” Int J Clin Pharmacol Res. 1993;13(5):275-80. http://www.ncbi.nlm.nih.gov/pubmed/8200722?dopt=Abstract, 29 Braga PC, Rampoldi C et al “In vitro rheological assessment of mucolytic activity induced by seaprose.” Pharmacol Res 1990;22(5):611-617. http://www.ncbi.nlm.nih.gov/pubmed/2277801
And finally, studies have shown that seaprose is highly effective in relieving both the pain and inflammation of veins associated with thrombophlebitis, resulting from blood clot formation in the veins–a painful condition in and of itself but also closely related to deep vein thrombosis (DVT).30 Bracale G, Selvetella L. “Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase.” Minerva Cardioangiol. 1996 Oct;44(10):515-24. http://www.ncbi.nlm.nih.gov/pubmed/9091835
Serrapeptase
Whenever we discuss seaprose-S, we have to mention serrapeptase, which is used in many formulas instead of seaprose–and sometimes along with it. Like seaprose, serrapeptase has remarkable anti-inflammatory and anti-edemic (counters swelling and fluid retention) activity in a number of tissues. And like seaprose, it can reduce pain and help clear mucous from the lungs by reducing neutrophil numbers, thus thinning the mucous in the lungs of patients with chronic airway diseases. So why not use serrapeptase in my “ideal” formula? Three reasons:
- Its quality tends to be inconsistent.
- It can cause intestinal distress.
- It is very sensitive to stomach acid, which means it has to be enteric coated. Unfortunately, the technology for enterically coated capsules is not reliable (which is why you normally find enteric coating used only on hard tablets or on hard beads inside capsules (as in cold capsules).
Seaprose-S, on the other hand is:
- Manufactured in Japan and is of consistent high quality.
- Causes virtually no intestinal distress.
- Unaffected by stomach acid so it does not require enteric coating.
- And studies have shown that it is more effective than serrapeptase — 85% vs 65%. Bracale.
The bottom line is that serrapeptase is harder to work with, produces side effects, can’t handle stomach acid, and has to be used in an enterically coated capsule. And since the formula as is already provides all the benefits offered by serrapeptase without those problems, why use it?
The Non-enzymes in a Systemic Proteolytic Enzyme Formula
Rutin is a bioflavonoid found in citrus and buckwheat that helps the body utilize vitamin C and produce collagen (skin’s main building blocks). In addition, it can be used to treat conditions such as hemorrhoids, varicose veins, high blood pressure, and to reduce cholesterol levels. However, the reasons that I include rutin in this formula are that rutin:
- Increases the elasticity of the arterial walls, which, in turn, promotes greater blood flow and improved vascular health.31 Kuzan A1, Chwilkowska A, Kobielarz M, Pezowicz C, Gamian A. “Glycation of extracellular matrix proteins and its role in atherosclerosis. Postepy Hig Med Dosw (Online). 2012 Oct 29;66:804-9. http://www.ncbi.nlm.nih.gov/pubmed/23175335
- Improves capillary strength and helps regulate their permeability.32 James Couch. “Rutin for Capillaries. USDA Yearbook of Agriculture. 1947 p711. http://naldc.nal.usda.gov/download/IND43893991/PDF
- Works as an anti-inflammatory.33 Teresita Guardia, Alejandra Ester Rotelli, et al. “Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.” Il Farmaco Volume 56, Issue 9, 1 August 2001, Pages 683–687. , 34 Selloum L1, Bouriche H, Tigrine C, Boudoukha C. “Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation.” Exp Toxicol Pathol. 2003 Mar;54(4):313-8. http://www.ncbi.nlm.nih.gov/pubmed/12710715
- And it may be anti-carcinogenic.35 Drewa G, Schachtschabel DO, Palgan K, et al. “The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice.” Neoplasma 1998;45:266-71. http://www.ncbi.nlm.nih.gov/pubmed/9890672 , 36 Webster RP, Gawde MD, Bhattacharya RK. “Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats.” Cancer Lett 1996;109:185-91.
- Inhibits the formation of blood clots, which can be helpful in preventing DVT. 37Reema Jasuja, Freda H. Passam, Daniel R. Kennedy, Robert Flaumenhaft, et al. “Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents.” J Clin Invest. 2012; 122(6):2104–2113. http://www.jci.org/articles/view/61228/version/2/pdf/render
And finally, as we discussed earlier, rutin–along with trypsin (as found in the fungal pancreatin)–enhances the effect of the bromelain. The bottom line is that rutin mirrors the benefits of the proteolytic enzymes in the formula but does so using different, complementary pathways.
Ginger is a COX-2 inhibitor. The COX-2 enzyme plays a key role in the inflammation process, which is a normal, healthy attempt by the body to heal itself. However, when inflammation gets out of control (such as in the case of arthritis or other chronic inflammatory disorders), ongoing pain and discomfort is the result–not to mention that systemic inflammation is considered to be a contributing factor to catastrophic illnesses such as heart disease and cancer. A botanical COX-2 inhibitor such as found in ginger can block the action of the COX-2 enzyme in much the same way as prescription drugs do, but without the side effects. I’ve written before about ginger’s benefits when it comes to controlling joint inflammation, but the benefits of controlling systemic inflammation go far beyond that.
As it turns out, ginger’s abilities to reduce oxidative stress, apoptosis, and inflammation have a protective effect on the diabetic brain,38 El-Akabawy G, El-Kholy W. “Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats.” Ann Anat. 2014 May;196(2-3):119-28. http://www.ncbi.nlm.nih.gov/pubmed/24680376 as well as sugar induced inflammatory damage to the kidneys.39 Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. “Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats.” BMC Complement Altern Med. 2014 May 27;14(1):174. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047007/
In addition, a growing number of experimental studies suggest that 6-shogaol, a key bioactive component found in ginger, may play an important role as a memory-enhancing and anti-oxidant agent against neurological diseases. 6-Shogaol has also recently been shown to have anti-neuroinflammatory effects, which is important when it comes to protecting against the loss of brain function and neurological disorders such as Parkinson’s disease.40 Moon M, Kim HG, Choi JG, Oh H, et al. “6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia.” Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13. http://www.ncbi.nlm.nih.gov/pubmed/24796668 And it may account for ginger’s purported benefits when it comes to Alzheimer’s.41 Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. “Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats.” Rejuvenation Res. 2013 Apr;16(2):124-33. http://www.ncbi.nlm.nih.gov/pubmed/23374025
The bottom line is that ginger’s anti-inflammatory benefits are spread systemically throughout the body and, as with rutin, accomplish these effects using different, complementary pathways than do the proteolytic enzymes in the formula. Like rutin, ginger provides a perfect complement to our systemic, proteolytic enzyme formula.
CMIK-pH+™ Mineral Blend
When it comes to proteolytic enzymes, most of them (other than pepsin) work best in a neutral to slightly alkaline environment. Optimizing that environment, then, becomes crucial for maximizing the beneficial effects of the formula. (Note: enterically coating a capsule does nothing to change the actual environment.)
The big breakthrough in this formula is the addition of a pH buffering system (the CMIK-pH+™ Mineral Blend). This buffer provides a number of benefits, but the primary one is that it helps optimize the pH of all your soft tissue. Since your body will do anything to keep your blood’s pH in a narrow range, that means it robs Peter to pay Paul. It steals minerals and lowers pH in your soft tissue to prevent your blood from changing pH if your diet is too acid forming–as is most people’s. If you eat meat, dairy, cooked grains, desserts, and most fruit, then your diet is indeed too acid forming. The bottom line is that by raising soft tissue pH, you dramatically improve the ability of proteolytic enzymes to root out CIC’s embedded in that soft tissue, thus relieving allergies and reducing the possibility of autoimmune conditions/diseases.
The addition of a pH buffering system to a proteolytic enzyme formula is so revolutionary and effective, it was awarded a US Patent.
Buying a Proteolytic Enzyme Formula
As I’ve stated previously, when comparing enzymes, if you want an apples to apples comparison, you need to compare activity levels, not milligrams. The internationally recognized and accepted standard for measurement is by Food Chemicals Codex (FCC) Units. These are usually expressed in different activity units for each type of enzyme. For the above formula, that would be:
- Protease — 300,000 HUT (Hemoglobin Units, Tyrosine basis).
- Fungal Pancreatin — 1,200 USP (United States Pharmacopeia).
- Nattokinase — 540 FU (Fibrinolytic Units) refers to nattokinase’s ability to break down the blood clotting enzyme, fibrin.
- Seaprose S — 15,000 U (quite simply, an enzyme Unit).
- Papain — 72 MCU (Milk Clotting Units). Based on how fast the enzyme digests milk protein. Sometimes listed as PU (Papain Units), which are equivalent to 0.1 MCU.
- Bromelain — 336 GDU (Gelatin Digesting Units). Based on how fast the enzyme digests gelatin. 1 MCU is equivalent to 0.67 GDU.
- Amylase — 3,000 SKB (named after the creators of the test Sandstedt, Kneen, and Blish ) or DU (used in the brewing industry). SKB and DU match up one to one.
- Lipase — 192 FIP. Formerly measured in LU (Lipase Units), but now more commonly measured in FIP units (i.e., according to the test methods of the Fédération Internationale Pharmaceutique). On a unit to unit basis, 1 FIP is equivalent to 10 LU.
Conclusion
The regular use of systemic, proteolytic enzymes can be an invaluable addition to your daily health regimen. From removing dental plaque to protecting and repairing your cardiovascular system, from reducing inflammation throughout the entire body to speeding up the recovery times of athletes and post-surgical patients.42 Duskova M, Wald M. “Orally administered proteases in aesthetic surgery.” Aesthetic Plast Surg. 1999 Jan;23(1):41-4. http://www.ncbi.nlm.nih.gov/pubmed/10022937 The bottom line is that supplementation with a good systemic proteolytic enzyme formula such as we’ve discussed here today is essential. To summarize the key benefits:
- Reduced inflammation: Inflammation is a natural response of the body to injury. However, excessive inflammation retards the healing process. Proteolytic enzymes reduce inflammation by neutralizing the bio-chemicals of inflammation (bradykinins and pro-inflammatory eicosanoids) to levels where the synthesis, repair and regeneration of injured tissues can take place. Reducing inflammation can have immediate impact on improved heart health, cancer prevention and recovery, and Alzheimer’s prevention. It also helps speed up recovery from sprains, strains, fractures, bruises, contusions, surgery — and arthritis.
- Cleansing the blood of debris: Proteolytic enzymes are the primary tools the body uses to “digest” organic debris in the circulatory and lymph systems. Supplementing merely improves the effectiveness of the process.
- Dissolving fibrin in the blood, reducing the risk of clots: Nattokinase, in particular, is extremely effective at improving the “quality” of blood cells, optimizing the ability of blood to flow through the circulatory system, and reducing the risk of clots. This is extremely important in reducing the risk of stroke. It also makes using proteolytic enzymes during long plane flights to minimize the potential of blood clots in the legs an obvious choice.
- Maximized immune system: The primary vehicle the immune system uses for destroying invaders is enzymes. Macrophages, for example, literally digest invaders with proteolytic enzymes. Supplementation significantly improves the ability of your immune system to do its job.
- Killing of bacteria, viruses, molds, and fungi: Bacteria, viruses, molds, and fungi are protein/amino acid based. Proteolytic enzymes taken between meals literally go into the bloodstream and digest these invaders.
- Elimination of autoimmune diseases: In Lessons from the Miracle Doctors, I cover in detail the process whereby large undigested proteins make their way into the bloodstream and form CICs (Circulating Immune Complexes), which trigger allergies and autoimmune diseases. Supplemental proteolytic enzymes clean CICs out of the body, thereby reducing allergies and autoimmune conditions. In addition, this helps with sinusitis and asthma.
- Dissolving of scar tissue: Scar tissue is made of protein. Proteolytic enzymes can effectively “digest” scar tissue — particularly in the circulatory system.
- And finally, a properly designed supplemental proteolytic enzyme formula can help.reduce the symptoms of MS, clean out the lungs, and aid in detoxing.
The following actions will improve the benefits you derive from supplementing with proteolytics:
- Add more raw foods to your diet.
- Cut out (or at least cut down) on processed foods.
- Cut out (or at least cut down) on cooked foods.
- Chew your food properly so they thoroughly mix with the enzymes in your saliva.
- Drink alkalinized water–but not with your meals as it dilutes your digestive juices.
Dosing
For most people, taking their proteolytic enzymes in the dosage described above on a daily basis, at least 1 hour before eating is all that’s needed to give you the best shot at maintaining a healthy inner environment. Since that dosage is likely to be contained in more than one capsule, it’s best to spread it out over the course of the day–say one capsule three times a day, assuming the dosage is contained in three capsules.
For detoxification (really more of an overhaul and repair of your entire body), start by doubling the maintenance dosage, then tripling it if needed, and even quadrupling it — until you notice benefits, or as recommended by your health professional. You will want to run a detox program for a minimum of 30 days to as long as 12-24 months — depending on the state of your health and how much damage you are trying to repair.
For performance athletes, or people just interested in optimum cardiovascular health or faster recovery and repair, you can build to (and continue on) three to four times the maintenance dosage per day for as long as required.
Can you take too much? Absolutely! As we discussed, one of the benefits of a good proteolytic enzyme formula is that it works as a natural blood thinner. But as the old saying goes, “Too much of a good thing is bad.” Unlike pharmaceutical blood thinners, though, this is unlikely to ever manifest as bruises suddenly appearing all over your body. However, if your dosage goes higher than your body can handle, you will notice an increased tendency to have spontaneous nose bleeds or increased rectal bleeding if you have any hemorrhoids. If you notice any of these symptoms or have any intestinal discomfort, or discomfort of any kind, back down your dosage until the symptoms disappear.
Also, it should be noted that although supplemental proteolytic enzymes significantly decrease the risk of both ischemic and transient ischemic strokes (those caused by blood clots and that account for 87% of all strokes), they do, on the other hand, increase the risk of damage if you have a hemorrhagic stroke (a bleeding stroke caused by a weakened blood vessel) because clotting may take longer. Then again, proteolytic enzymes are just as likely to strengthen that blood vessel in the first place, thereby reducing your odds of having a hemorrhagic stroke at all.
Testimonial
And finally, one of the best testimonials I ever received on the benefits of systemic, proteolytic enzymes, was sent to me shortly after I released my own version of the formula in December of 2003. And based on the detail included in that testimonial and the breadth of the conditions discussed, plus the fact that it came from a health professional, it’s still one of the best. Check it out.
(Originally published 08/26/2006. Updated 07/21/2014.)
References
| ↑1 | Hedstrom, L. (Dec 2002). “Serine protease mechanism and specificity.” Chem Rev 102 (12): 4501–24. http://www.ncbi.nlm.nih.gov/pubmed/12475199 |
|---|---|
| ↑2 | Chapman HA, Riese RJ, Shi GP (1997). “Emerging roles for cysteine proteases in human biology.” Annu. Rev. Physiol. 59: 63–88. http://www.ncbi.nlm.nih.gov/pubmed/9074757 |
| ↑3 | Arazi A1, Neumann AU. “Modeling immune complex-mediated autoimmune inflammation.” J Theor Biol. 2010 Dec 7;267(3):426-36. http://www.ncbi.nlm.nih.gov/pubmed/20832412 |
| ↑4 | P O Cano, L M Jerry, J P Sladowski, and C K Osterland. “Circulating immune complexes in systemic lupus erythematosus.” Clin Exp Immunol. Aug 1977; 29(2): 197–204. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541106/pdf/clinexpimmunol00234-0013.pdf |
| ↑5 | Stauder G, Ransberger K, Streichhan P, Van Schaik W, Pollinger W. “The use of hydrolytic enzymes as adjuvant therapy in AIDS/ARC/LAS patients.” Biomed Pharmacother. 1988;42(1):31-4. http://www.ncbi.nlm.nih.gov/pubmed/3408806 |
| ↑6 | Cecil Adams. “Is it aerodynamically impossible for bumblebees to fly?” The Straight Dope. May 4, 1990. (Accessed 24 Jun 2014.) http://www.straightdope.com/columns/read/1076/is-it-aerodynamically-impossible-for-bumblebees-to-fly |
| ↑7 | Brad Rachman, “Unique Features and Application of Non-Animal Derived Enzymes.” Clinical Nutrition Insights. 510 8/97 Vol. 5, No. 10. (Accessed 24 Jun 2014.) http://acudoc.com/Digestive%20Enzymes.PDF |
| ↑8 | Laura P. Hale. “Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.” International Immunopharmacology. Volume 4, Issue 2, February 2004, Pages 255–264. http://www.sciencedirect.com/science/article/pii/S1567576903002972 |
| ↑9 | KOLAC C., STREICHHAN P., LEHR C.-M. “Oral bioavailability of proteolytic enzymes.” European journal of pharmaceutics and biopharmaceutics. 1996, vol. 42, no4, pp. 222-232 (68 ref.) http://cat.inist.fr/?aModele=afficheN&cpsidt=3191444 |
| ↑10 | http://www.ncbi.nlm.nih.gov/pubmed/?term=nattokinase |
| ↑11 | http://www.ncbi.nlm.nih.gov/pubmed/?term=bromelain+inflammation |
| ↑12 | Stauder G. “Pharmacological effects of oral enzyme combinations.” Cas Lek Cesk. 1995 Oct 4;134(19):620-4. http://www.ncbi.nlm.nih.gov/pubmed/7585874 |
| ↑13 | Nouza K. “Systemic enzyme therapy in diseases of the vascular system.” Bratisl Lek Listy. 1995 Oct;96(10):566-9. http://www.ncbi.nlm.nih.gov/pubmed/8620329 |
| ↑14 | Beuth J. “Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction?” Integr Cancer Ther. 2008 Dec;7(4):311-6. doi: 10.1177/1534735408327251. http://www.ncbi.nlm.nih.gov/pubmed/19116226 |
| ↑15 | Desser L, Rehberger A, Paukovits W. “Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro.” Cancer Biother 1994;9:253-63. http://www.ncbi.nlm.nih.gov/pubmed/7529614 |
| ↑16 | Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. “Bromelain treatment decreases neutrophil migration to sites of inflammation.” Clin Immunol. 2008 Jul;128(1):66-74. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516972/ |
| ↑17 | Tassman G, Zafran J, Zayon G. “A double-blind crossover study of a plant proteolytic enzyme in oral surgery.” J Dent Med 1965;20:51–4. http://www.ncbi.nlm.nih.gov/pubmed/14282458 |
| ↑18 | Cirelli MG. “Treatment of inflammation and edema with bromelain.” Delaware Med J 1962;34:159–67. http://www.ncbi.nlm.nih.gov/pubmed/13879585 |
| ↑19 | Brien S, Lewith G, Walker A, Hicks SM, Middleton D. “Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.” Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538506/ |
| ↑20 | Akhtar NM1, Naseer R, Farooqi AZ, Aziz W, Nazir M. “Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee–a double-blind prospective randomized study.” Clin Rheumatol. 2004 Oct;23(5):410-5. http://www.ncbi.nlm.nih.gov/pubmed/15278753 |
| ↑21 | Heinicke R, van der Wal L, Yokoyama M. “Effect of bromelain (Ananase) on human platelet aggregation.” Experientia 1972;28:844–5. http://www.ncbi.nlm.nih.gov/pubmed/4658882 |
| ↑22 | Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, et al. “Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium.” Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581828/ |
| ↑23 | Rakhimov MR. “Anti-inflammatory activity of domestic papain].” Eksp Klin Farmakol. 2001 Jul-Aug;64(4):48-9. http://www.ncbi.nlm.nih.gov/pubmed/11589110 |
| ↑24 | Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. “Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan.” Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347. http://www.ncbi.nlm.nih.gov/pubmed/8280151 |
| ↑25 | Murakami K1, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. “Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food.” Food Funct. 2012 Jun;3(6):674-8. http://www.ncbi.nlm.nih.gov/pubmed/22453301 |
| ↑26 | Kim JY, Gum SN, Paik JK, et al. “Effects of nattokinase on blood pressure: a randomized, controlled trial.” Hypertens Res. 2008;31(8):1583-1588. http://www.ncbi.nlm.nih.gov/pubmed/18971533 |
| ↑27 | Fossati A. “Anti-inflammatory effects of seaprose-S on various inflammation models.” Drugs Exp Clin Res. 1999;25(6):263-70. http://www.ncbi.nlm.nih.gov/pubmed/10713864 |
| ↑28 | Moretti M, Bertoli E, Bulgarelli S, Testoni C, et al. “Effects of seaprose on sputum biochemical components in chronic bronchitic patients: a double-blind study vs placebo.” Int J Clin Pharmacol Res. 1993;13(5):275-80. http://www.ncbi.nlm.nih.gov/pubmed/8200722?dopt=Abstract |
| ↑29 | Braga PC, Rampoldi C et al “In vitro rheological assessment of mucolytic activity induced by seaprose.” Pharmacol Res 1990;22(5):611-617. http://www.ncbi.nlm.nih.gov/pubmed/2277801 |
| ↑30 | Bracale G, Selvetella L. “Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase.” Minerva Cardioangiol. 1996 Oct;44(10):515-24. http://www.ncbi.nlm.nih.gov/pubmed/9091835 |
| ↑31 | Kuzan A1, Chwilkowska A, Kobielarz M, Pezowicz C, Gamian A. “Glycation of extracellular matrix proteins and its role in atherosclerosis. Postepy Hig Med Dosw (Online). 2012 Oct 29;66:804-9. http://www.ncbi.nlm.nih.gov/pubmed/23175335 |
| ↑32 | James Couch. “Rutin for Capillaries. USDA Yearbook of Agriculture. 1947 p711. http://naldc.nal.usda.gov/download/IND43893991/PDF |
| ↑33 | Teresita Guardia, Alejandra Ester Rotelli, et al. “Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.” Il Farmaco Volume 56, Issue 9, 1 August 2001, Pages 683–687. |
| ↑34 | Selloum L1, Bouriche H, Tigrine C, Boudoukha C. “Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation.” Exp Toxicol Pathol. 2003 Mar;54(4):313-8. http://www.ncbi.nlm.nih.gov/pubmed/12710715 |
| ↑35 | Drewa G, Schachtschabel DO, Palgan K, et al. “The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice.” Neoplasma 1998;45:266-71. http://www.ncbi.nlm.nih.gov/pubmed/9890672 |
| ↑36 | Webster RP, Gawde MD, Bhattacharya RK. “Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats.” Cancer Lett 1996;109:185-91. |
| ↑37 | Reema Jasuja, Freda H. Passam, Daniel R. Kennedy, Robert Flaumenhaft, et al. “Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents.” J Clin Invest. 2012; 122(6):2104–2113. http://www.jci.org/articles/view/61228/version/2/pdf/render |
| ↑38 | El-Akabawy G, El-Kholy W. “Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats.” Ann Anat. 2014 May;196(2-3):119-28. http://www.ncbi.nlm.nih.gov/pubmed/24680376 |
| ↑39 | Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. “Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats.” BMC Complement Altern Med. 2014 May 27;14(1):174. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047007/ |
| ↑40 | Moon M, Kim HG, Choi JG, Oh H, et al. “6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia.” Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13. http://www.ncbi.nlm.nih.gov/pubmed/24796668 |
| ↑41 | Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. “Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats.” Rejuvenation Res. 2013 Apr;16(2):124-33. http://www.ncbi.nlm.nih.gov/pubmed/23374025 |
| ↑42 | Duskova M, Wald M. “Orally administered proteases in aesthetic surgery.” Aesthetic Plast Surg. 1999 Jan;23(1):41-4. http://www.ncbi.nlm.nih.gov/pubmed/10022937 |
If I take Digestive enzymes
If I take Digestive enzymes with food, do I need to also take the Proteolytic Enzymes? Also, my son, who is 19 yoa has congenital liver fibrosis. I give him Digestive Enzymes with each meal. Should I give him the Proteolytic Enzymes as well or in lieu of the Digestive Enzymes? Thanks in advance for your reply. And where do I buy?
Looking for the answer to the
You can find them here: http://Www.baselinenutritionals.com/Products/Phi-Zymes-90.Php/
Richard,
Just scroll down to
Richard, Just scroll down to see answer. See this note: “Submitted by BaselineFoundation on April 18, 2011 – 7:57am.”
Robert o young says there is
Robert o young says there is no such thing as bad bacteria get over it
A quote from one books I found on a site
He also says infection is an illusion
He’s wrong about bacteria right? If he was right then sauerkraut would be worthless to rebuild good bacteria by milling of bad
Also Keith Scott mumby says milk is deadly has no place in body that goes for raw milktoo it doesn’t belong in body.
So that means organic grass fed pasteurized kefire is worthless because it’s milk which Keith says has killed people
Thank you for the article.
Thank you for the article. There are tons of articles on intergrative health and alternative therapies. The problem is which brand of vitamin to use. How does the consumer know which brand actually has the appropriate amount of active ingredients in it? does cost effect the potency? the cost is sometimes prohibited for some brands, so does paying more money ensure quality. Do you have any suggestions on excellent brands of supplements that work? Thank you, A guest
Dear Guest, there are a few products Jon recommends here: http://www.jonbarron.org/natural-health/program-dietary-supplements-product-recommendations
Hi Diane,
Digestive enzyme
Hi Diane,
Digestive enzyme formulas and proteolytic enzyme formulas share similarities in compositions, but are very different in purpose. Digestive enzymes are designed to be taken with meals to aid in the digestion of those meals. Proteolytic enzymes, on the other hand, are designed to be taken without food. You do not want them used up digesting food. You want them to enter the bloodstream and work there. Taking one does not eliminate the need for the other. For a complete explanation, read Jon Barron’s three part series on enzymes. http://www.jonbarron.org/enzymes/nl031027/digestive-health-proteolytic-enzyme
As for your son, for obvious legal reasons, we cannot diagnose or prescribe for specific medical conditions. But again, in non-medical terms, taking digestive enzymes with food is different from taking proteolytic enzymes between meals. Again, Jon’s series of newsletters on enzymes will explain the difference.
hi ……just wondering if am
hi ……just wondering if am taking aspirin cos have small vessel disease…….am taking 2 which i really don’t want to or like doing…….what would be the recommended doseof the enzyme formula to equate with 2 daily aspirin…….if 10 or 12 tabs is the alternative enzyme dosing it would be for me, not possible, as i could not afford as i would be going through approx 3 – 4 bottles a month…..but if a lower dose
(which i think you hint at as it is very effective) is recommended i totally would love to change to it…..thanks janice….
I recently moved to New
I recently moved to New Mexico and found that in the early spring when the pollen as active from the Juniper trees I have serious allergies (itchy eyes, sneezing, scratchy throat, inflamation under eyes and some throat, runny to stuffy nose, fatigue). After the blooming passes the symptoms subside. I am doing a colon cleanse and considering the Phase 2 and 3 cleanse. Is juniper in the phase 2 or 3 detox formulas and if so would taking the formula be supportive or could it trigger allergy symptoms when taken internally? Thanks so much.
Will proteolytic enzymes
Will proteolytic enzymes assist in reducing surgical adhesions as a result of abdominal surgery. I saw a comment they work on scar tissue.
Is there an answer to this
Is there an answer to this question?
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe for specific medical conditions.
can children as young as 12
can children as young as 12 years old take proteolytic enzymes to help with asthma and sinus ??
Some children, with their
Some children, with their pediatrician’s permission and guidance, do take proteolytic enzymes with beneficial results. You do want to have your pediatrician monitor the dosage since one of the benefits of proteolytic enzymes is that they decrease the tendency of blood cells to clump together. At the right levels, this is positive, but if the dosage is too high it can lead to a reduced ability of blood to clot – and in a smaller child’s body, that can happen at lower dosages.
this is one of the few
this is one of the few examples of BF responses that refer to “the right dosage” for proteolytic enzymes which is a subject close to my heart (forgive the pun).. clearly one can expect different outcomes from supplementation depending on dosage. You say as much in your above response. So where might that parent find advice to avoid overdosing her child? Whilst recognising the ban on prescription which applies to JB et al I cannot help but conclude that the time is nigh when those who profit from supplementation products need take more responsibility for their application. In effect i guess i am suggesting that Jon should find a way to put his mouth where his money comes from when it comes to guidance on dosing for the supplements he designs and causes to be manufactured.. max
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe. To name a particular dosage in this case would amount to prescribing for a child. We can list general guidelines for nutrients as “nutritional support” supplements for adults, but cannot recommend specific dosages for children. However, most pediatricians use the weight method for prescribing supplements for children. Assuming an average adult weight of 150 lbs, then a child of 75 lbs would get half the adult dose. A child of 50 lbs would get 1/3 the dose. Check with your pediatrician to see if they use that method for calculating supplement doses for your child.
What should be the
What should be the recommended daily amount of Protease? i was wanting to use it to cleanse my blood free from toxins
That question as phrased
That question as phrased doesn’t actually have meaning. Protease is a general description for any enzyme that breaks down proteins. It’s a bit like asking, “What would be the recommended daily amount of vegetable.” It depends on what specific type of proteases you use, what’s their strength, how they’re combined in a formula, etc. For instructions on how to use such a formula, check out http://www.baselinenutritionals.com/products/phi-zymes-90.php. Keep in mind that different formulas, will be used differently.
Dear Dr. Barron,
what is your
Dear Dr. Barron,
what is your input about the “Pauling Therapy” which recommends massive amounts of Vitamin C daily, to reverse arteriosclerosis.
Does it work, or is it another idea that does nothing.
Thanks
Hi George,
The evidence for
Hi George,
The evidence for the benefits of “Pauling Therapy” with cancer are stronger than for heart disease. But that said, you need to make sure that you’re actually doing the therapy as Pauling advocated. The key here is that virtually all significant studies on vitamin C — particularly those done by Linus Pauling — were done at 4,000 mg a day administered intravenously. If you're trying to evaluate a health protocol, you actually have to use the protocol in question if you wish to assess it. You can't arbitrarily cut doses to 500 mg a day and conclude the protocol doesn't work.
Yes information given in this
Yes information given in this article is worth a praise and everyone should read benefit in excellent healthy lifestyles without use of medicine.God bless you.
How could this relate to MS
How could this relate to MS and immune system failure ?
would also like the answer to
would also like the answer to this question since I have MS and fibromyalgia and ankylosing sponylitis
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe for specific medical conditions – merely provide information. With that said, you might want to check on Jon’s newsletter on MS, which specifically addresses the issue of MS and the immune system. http://www.jonbarron.org/immunity/boost-immune-system-ms-multiple-sclerosis
Absolutely GREAT stuff!
Absolutely GREAT stuff! Thanks for writing this info and for sharing this. I will do what I can to get the word out about you and your organization. We need more people like you!!
Thanks a million.
Kathy Holfelder
My husband has had numerous
My husband has had numerous surgeries on his leg (8 so far)and has a problem with extensive scar tisue formation at his prosthetic knee. He is already on supplements and Alkalinized water. What phizyme product do you recommend for him?
Well.I am more than delighted
Well.I am more than delighted to add myself to the list of Phi-Zymes users who have experienced dental benefits.Admittedly,I started on Phi-Zymes,April 4th 2012 to be exact,for the athletic/cardiovascular benefits that it promised,but sort of by coincidence I was way overdue on my dental appointment.I just hate the rough feeling on my teeth that not even a change of toothbrush can affect.Anyways,in well under two weeks(and that’s really stretching it)my teeth were as smoothe as any dentist visit I’ve ever had.It’s kinda ironic that what’s supposed to be a’minor beneficial side-effect’has in my case turned out to be the most immediate one.And a powerful one at that.Although I know the entire product is working systemically,at this point I can only speak with total clarity on the teeth benefits.The effects are just too overwhelming.Hopefully I can quantify my overall benefits at a later date.
I have just recently
I have just recently purchased (but haven’t yet received) Aqualyte and Ionyte to work on alkalinizing my blood PH. If you are familiar with these products, what is your view of their effectiveness? Will your new proteolytic enzyme product contain similar minerals? What is their source, by the way? Thank you. (If I were to purchase your new product, would taking Aqualyte or Ionyte be redundant/advisable?)
Aqualyte is a coral calcium
Aqualyte is a coral calcium product. For information on coral calcium read: http://www.jonbarron.org/heart-health/nl100809/calcium-intake-dietary-supplements
Ionyte is a trace mineral product. For information on trace minerals read: http://www.jonbarron.org/athletic-performance/barron-report-dietary-supplements-minerals
Would it be correct to assume
Would it be correct to assume that you should not take pHi-Zymes® if you’re taking Plavix?
Hi Carson,
That woud be a
Hi Carson, That woud be a customer support question for Baseline Nutritionals. Here at the foundation, we are a non-profit health information service only and do not handle direct questions about products. For Jon Barron’s formulas, any customer or product related questions need to be directed to: [email protected]. Thanks!
I just have to make this
I just have to make this comment about my experience with Phizymes. For as long as I can remember, I have had trouble with my ears plugging up when I fly, and my right ear in particular will stay plugged for two or three days. I travel weekly, so I’ve just gotten used to it. I also have bilateral pulsatile tinnitus to go along with the rest of my ear problems.
On my last two trips, an amazing thing has happened. My ears did not plug up, cleared gradually on decent, and completely by the time the plane pulled up to the gate. That’s four flights! In addition, my tinnitus has taken some kind of turn, it sounds different, and is milder – sometimes I have to stop and think to see if it’s still there.
I did not buy this product for my ears – this is an unexpected blessing. By the way, I’m taking three capsules when I get up in the morning, and three capsules an hour or so before dinner – usually around five PM. Will probably settle down to the recommended maintenance dose in a couple more weeks.
PS: Would like to know if there are any more tinnitus victims out there, and if they’re having a similar experience.
I have two questions that I
I have two questions that I need for you to answer if you can. I love your book and website. I have gluten sensitivity and have developed sensitivity to other foods. In April my tongue went numb and then I started experiencing numbness, tingling, and then eventually burning all over my body. I was diagnosed with Chronic Inflammation Demyelinating Polyneuropathy (CIDP). This is supposed to be an autoimmune disease of the peripheral nervous system. Would taking this help or hurt my condition since we are not to be taking immune boosting supplements for autoimmune diseases even though this can possibly eliminate it. I am a little confused over this because with everything I read, autoimmune diseases cannot tolerate immune boosting supplements. If you can give me some insight on this and this supplement, I would really appreciate it. I would also like for you to tell me how many to take a day to help with this condition since it roots out CIC’s embedded in the soft tissue which I think that these have settled in my peripheral nerves because my body was so overwhelmed with antibodies. My theory is that the body is attacking the antibodies that are imbedded in the nerves. If not taken care of, this can become like MS and become debilitating.
Although proteolytic enzymes
Although proteolytic enzymes help your immune system, they are NOT immune boosters. They don’t increase immune function. They merely eliminate some of those things, such as CIC’s, that overburden the immune system. As to how much to take, you would need to follow the directions on the product you purchased. Also, you might want to search the site for what Jon has to say about immunomodulators. For example: http://www.jonbarron.org/immunity/anatomy-physiology-optimizing-immune-system
Thank you for the quick
Thank you for the quick response. I have another question. If the protease is made from fungus and I am allergic to molds and fungus can I still take it? Since the protease is made from fungus (fungus that made this protease is not in the enzyme) will this still effect me due to it was made from it? (I hope that makes sense)Also,is there dairy in it? I don’t think I seen where there was any dairy. If you could give me some insight on this also, I would really appreciate it.
Most food grade enzymes are
Most food grade enzymes are made using aspergillus as a fermenting agent. When the enzymes are extracted and purified, there is virtually no aspergillus left – but virtually does not mean none. For most people, the amount is so minute that there is no problem. But those who are extremely sensitive to aspergillus mold may not be able to use many products that use aspergillus as a fermenting agent.
Thank you for generously
Thank you for generously sharing your knowledge. My son has Hepatitis C. He can’t afford traditional medical treatment. What would you suggest he try? Every Doctor I’ve talked to say he shouldn’t take any herbal remedies for fear of liver damage or speeding up the virus.
If you search our website,
If you search our website, you can find articles such as this one: http://www.jonbarron.org/natural-health/bl061110/blog-hepatitis-C
However, most lead back to understanding the "Baseline of Health" program, which is outlined in Jon Barron's book "Lessons From the Miracle Doctors." There are no magic bullets to health, but a series of steps required to get your "Baseline of Health" up to an optimum level where the body heals itself.
I am taking 35% FOOD GRADE
I am taking 35% FOOD GRADE H202 BATHS for cancer. I take proteolytic enzymes so the H202 can penetrate the cancerous cells. I take these first thing in the morning on an empty stomach before my H202 BATHS. I plan to take at least 60 or more baths. These baths kill parasites, candida, fungus and bacteria.
What are your thoughts on
What are your thoughts on serrapeptase and why isn't it included in pHi-Zymes?
Jon talks about this in some
Jon talks about this in some detail in his earlier report on proteolytic enzymes. http://www.jonbarron.org/enzymes/natural-newsletter-digestive-health-part3
What is your evaluation of
What is your evaluation of anatabine as an agent for reducing inflammation?
It seems that this supplement
It seems that this supplement would be a God send to someone with sarcoidosis except for the fact that the immune system is already over active in sarcoidosis and this supplement boosts the immune system. If it regulated it, that would be a diffferent matter. Could you comment on this please. Thank you, Jane.
I believe you may have
I believe you may have misunderstood the information on pHi-Zymes. They do not boost the immune system. What they do is, by removing circulating immune complexes, take load off the immune system so that your immune system can work more effectively with a lowered response. In that sense, they actually help throttle down immune response. That said, in addition to proteolytic enzymes, you might also want to look at immunomodulators, which are nutraceuticals that have the ability to tone down an overactive immune system. http://www.jonbarron.org/article/anatomy-and-physiology-immune-system-part-4
Hi there,
Hi there,
Thanks for all the information you provide on here. I have recently started supplementing with both food enzymes and proteolytics in between meals based on a few of your articles. My question is regarding their effects on probiotic content – not so much the digestive enzymes as much as the proteolytics.
In the same way proteolytics are recommended to be taken on an empty stomach, many probiotics are also recommended, also. Therefore, I’ve been taking both of them together when I wake in the morning and waiting over an hour before having my first meal. Regardless of whether they are taken together or not, my question is the effects of proteolytics both on the good bacteria in the gut as well as on the efficacy of probiotics taken while on a regimen of probiotics.
So, question: If proteolytics affect the proteins and life/death of bacteria, yeasts, fungi, and molds, etc., do they negatively affect the positive bacteria we want in our gut, or prevent the probiotics from working? I’m sure proteolytics work in many specific and, additionally, varied ways to affect many different areas of the body – but not being an ND or MD, etc., and not understanding molecular chemistry – this is one very important question that keeps entering my mind.
Thank you again for your many articles and all the help you provide, it is all much appreciated!
The enzymes need more
The enzymes need more extended contact with bacteria than they get in the intestinal tract to harm them. Once you build up levels in the blood, they work on pathogens in the blood 24/7. In the digestive tract, they are transient – and in fact, are absorbed into the bloodstream before they even reach the colon. They will not harm any established probiotic colonies in your intestinal tract. That said, you might not want to take proteolytic enzymes and probiotic supplements at exactly the same time as that would extend the time of contact with unestablished probiotics. Taking them 20 minutes apart on an empty stomach should be sufficient.
I see you mention Nattokinase
I see you mention Nattokinase in your article but I do not see it on the ingredient label for your enzymes. Curious why not?
Not sure what you’re
Not sure what you’re referring to. Jon uses nattokinase in his systemic proteolytic enzyme formula. http://www.baselinenutritionals.com/products/phi-zymes-450.php
The study published in
The study published in Molecular Cancer Research (Dec. 18, 2012) shows the link of proteolytic enzymes PRSS3 to aggressive prostate cancer. Is it any chance that the enzymes in pHi could act similar way.
There are several thousand
There are several thousand “different” proteolytic enzymes in the body that regulate a multitude of processes in the human body. Each enzyme is different; each process is different. PRSS3 is a specific proteolytic enzyme that may be associated with prostate cancer. As you may have noticed, it is not listed in the ingredients of pHi-Zymes.
To give you an analogous concept that may help you feel safer, it would be about like saying, “I read about a bacteria called MRSA that eats flesh. Is there any chance that the bacteria in yogurt could act in a similar way? As you can easily see in this example, different bacteria have entirely different properties – some harmful and some beneficial – and what one does has absolutely no connection to what others might do.
Make sense?
I am sold on proteolytic
I am sold on proteolytic enzymes but have been told that I have an old, mostly healed, ulcer, found on a routine endoscopy ( I could have told them that), and when I take them on an empty stomach I have severe pain. Any way I can get around this and utilize these wonderful God-given substances. I have several chronic health condition that could no doubt be helped by proteolytic enzymes.
As Jon has pointed out when
As Jon has pointed out when using enzymes with ulcers:
Digestive enzymes help with ulcers in two ways. First, they help digest so much of your meal during the 40-60 minutes of predigestion that your body requires less acid in the actual digestion phase. This means that taking digestive enzymes will help lower the levels of acid in your stomach. (Those who suffer from chronic low levels of acid need not worry. Digestive enzyme supplements help here too by breaking down so much food in the predigestion phase that less acid is actually required. And over time, decreased demand results in increased reserve capability.) Second, protease will begin breaking down the protective coating of the H. Pylori bacteria responsible for so many ulcers. In other words, it will actually begin to digest it. This is the prime reason digestive enzyme supplements are so helpful for those who have ulcers.
A cautionary note. There is one concern when using digestive enzymes with ulcers — and that’s if you have a severe existing ulcer. What happens is that the protease can actually begin to digest severely damaged stomach lining tissue. This can cause noticeable discomfort for several days. To avoid this discomfort, if you have a severe ulcer, start with small amounts of the supplement with your meals and build up slowly.
Jon,
Jon,
I’m a 64 year old man with cardio vascular disease (3 heart sents and 1totally blocked RCA. I have been taking a satin drug for about 20 years and starting to feel what I believe are the recognized side effects. Please note that high Cholesterol and CAD has been in my family Grandfather died on heart attack at 40years mom did better after bypass surgery lived to 70. It looks to me that at a minimum I should be taking a CoQ10 supplement and perhaps a proteoyletic enzymes. Your recommendations would be most appreciated.
Thank You
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe for specific medical conditions—merely provide information. With that in mind, you may find this article interesting: http://www.jonbarron.org/heart-health/how-to-prevent-heart-disease
Is there any evidence that
Is there any evidence that Proteolytic enzymes can help or reverse early stage congestive heart failure?
Same question re Atrial Fibrillation.
Thanks.
I can’t find how to order the
I can’t find how to order the blood cleanse on this site. This is my wife’s email as she handles all of this for me. read about you in Cancer step outside the box. I am interested in trying this.
Yes, The Baseline of Health
Yes, The Baseline of Health Foundation does not sell products, we are just an online non-profit health resource. Most formulas can be found at http://www.baselinenutritionals.com
Dear Mr Jon B your site with
Dear Mr Jon B your site with its most informative health topics was a blessing to me. for years I’ve become interested in natural healing with natural supplements and here it goes I found you, I down loaded the Dr. Miracle book read it in 2 days and discover that even when you think your doing something right you may not be doing it CORRECTLY. THANK YOU for your years of heard work thru research, travel time, improving exiting supplement an all the good stuff in behalf of humanity. I as well as billions of people will begin to enjoy a healthier EXISTENEC and with continues education and reeducating ourselves using your indebt knowledge we can begin to enjoy LIFE. Today I can begin to heal not just using the rite combo of supplements but using them CORRECLY.
rozy
Bahamas
Thank you Rosy!
Thank you Rosy!
Hi Jon,I have been involved
Hi Jon,I have been involved with and are very excited about the whole wellness industry.Your information is absolutely amazing and I have researched and spoken to a lot of very brilliant people around the world and I have to say you are my pick.Your description on topics is brilliant,very easy to understand and follow.
I have a lot of questions for you but one that I would like your view on and it follows recent discussions I have had with a leading Cardiologist and some Naturapaths in regards to the safety of using Serrapeptase or in your preference Serepia.
Their view are basically without going into major medical details – that the breakdown of calcified arterial plaque with the use of Serrapeptase can possibly lead to breaking up of the calicfied plaque and the fragmented piece or pieces cause blockages leading to strokes etc.
My view is that Serropeptase or Seaprose-S actually dissolves the calcified plaque regardless of the blockage whether it be 30%,40% or even higher without causing any tissue damage or blockage issues.I am not sure as to whether very high doses could possibly do this
I would love to hear your thoughts on this.
Regards,
Doug
The idea that proteolytic
The idea that proteolytic enzymes can trigger strokes by breaking off pieces of calcified plaque is not supported by any actual evidence or studies. In fact, all available evidence is that proteolytic enzymes significantly decrease the risk of both ischemic and transient ischemic strokes (those caused by blood clots and pieces of calcified plaque and that account for 87% of all strokes). HOWEVER, as Jon has pointed out, they do, increase the risk of damage if you have a hemorrhagic stroke (a bleeding stroke caused by a weakened blood vessel) because clotting may take longer—pretty much just the opposite problem. http://www.jstage.jst.go.jp/article/internalmedicine/47/5/47_5_467/_pdf
I have read that serrapeptase
I have read that serrapeptase can be helpful for vitreous eye floaters. Have you heard any reports that your formula is of benefit? Is endonase similar enough to serrapeptase that it is worth a try?
The vitreous humor is a clear
The vitreous humor is a clear gel-like substance that is composed mostly of water and gives the eye its shape and form. Floaters are little fibers that are normally attached to the retina (there are millions of them) that come loose and float about in the vitreous humor. Most people have had some since they were children. Over time, they either dissolve or the visual cortex in your brain learns to ignore them so you don’t see them anymore. As you age, and the vitreous humor shrinks, some more fibers can break free, their numbers can increase. and you can see them again…until they either dissolve or your brain learns to filter them out once again.
As for serrapeptase, there are anecdotal reports that it can help, but there is a problem with those reports. There is no blood circulation into the vitreous humor so no easy way for the serrapeptase to get in there. It is more likely that the floaters dissolved over time or people’s brains did the filtering out thing while they were taking the serrapeptase and they credited serrapeptase for the result.
I shared your article with a
I shared your article with a friend, which he and I are on the same page regarding healthy diet and what we consume. The question is this: What are the ingredients in your formulas and are they all natural … not a big fan of taking anything manufactured in a lab
Thanks, John
As asked, your question is a
As asked, your question is a bit ambiguous. Being natural and being manufactured in a “lab” are not mutually exclusive. In fact, virtually all supplement ingredients are manufactured in a lab. Perhaps the question that you really want to ask is, “Are all of the ingredients in Jon’s formulas naturally sourced, or are they synthetic?” And the answer to that is that Jon uses only naturally sourced ingredients—even if most of those involve laboratory procedures in their production and/or extraction. For example, most of the enzymes referred to in the above article are manufactured by fermenting nutrients in a vat of specially cultivated fungi—usually a strain of aspergillus—that produce the desired enzymes. These enzymes are then run through another lab procedure in which they are then extracted and purified. In other words, they’re naturally sourced using a laboratory derived process. However, this is miles away from synthetic beta carotene, for example, which is manufactured from benzene, which itself is extracted from acetylene gas. As Jon has pointed out on numerous occasions, synthetic nutritional ingredients are dubious at best. Make sense? The bottom line answer to your question is that Jon does not use synthetic nutrients in his formulas.
Dr Barron
Dr Barron
I have recovered from a bout of Autoimmune Hepatitis and my liver results are now normal. My doctor is however concerned that my antibodies are positive.
I am currently consuming a liver supplement everyday and taking precautions to avoid raw seafood.
What is the risk of positive antibodies? What can I do to strengthen my immune system to prevent recurrence.
Thanks.
Positive antibodies are not a
Positive antibodies are not a problem in themselves. It’s what they might mean that is likely concerning to your doctor. Testing positive for certain antibodies means that your immune system has generated those antibodies in response to a perceived threat. You might want to check with your doctor, but a good guess would be that they were testing for antibodies that your body generates in response to hepatitis C, and the test showed positive, which means that your body is still responding to the presence of the disease. In other words, it might not be completely gone.
Can proteolytic enzymes and
Can proteolytic enzymes and probiotics be taken at the same time?
If there were extended
If there were extended contact between the two formulas, the proteolytics would indeed degrade the probiotics. But if taken together on an empty stomach, that doesn’t happen. If the stomach is empty, they actually spend very little time there and quickly pass into the small intestine. Once there, the proteolytics get absorbed into the bloodstream, while the probiotics make their way down into the colon. Long answer, short: yes, they can be taken at the same time on an empty stomach.
I seem to always have an
I seem to always have an adverse reaction to Papain (both in your formula and when eating papayas). Is there a way to get your formula without Papain, or to just take the Digestive Enzyme formula between meals ?
Thanks.
Yes, a small percentage of
Yes, a small percentage of people are allergic to papain and/or bromelain. Unfortunately, they both notably improve the efficacy of the systemic, proteolytic formula for those who are not. Taking the digestive’s between meals is an option. That’s what Jon did for years until he created a dedicated proteolytic formula. The other option is search for a company that makes a dedicated proteolytic formula without papain.
Doesn’t supplementing with
Doesn’t supplementing with digestive enzymes send a message to the pancreas to stop doing its job? Would it not be better to provide the body with Bitters to stimulate the pancreas to create all the enzymes the body needs?
The answer is an emphatic no!
The answer is an emphatic no! Using digestive enzymes does not signal the pancreas to stop doing its job. It signals it to stop “overdoing’ its job and thus burning itself out. Jon actually deals with this exact question in great detail in his next newsletter, due out on 8/4. As for bitters, they primarily stimulate the liver, not the pancreas. If they stimulated the pancreas to release digestive juices, they would be entering the digestive tract long before your meal arrived there and far too soon to be of any use. The bile released by the liver, on the other hand, is released into the gallbladder…where it is held until the meal actually enters the duodenum.
this is the best information
this is the best information i have read in years.i currently have a rash that started with my elbows and now is invading the rest of my body. i cant get rid of it. the skin specialist gave me one of the strongest creams out there yet after two weeks it is known to cause the adrenal to malfunction. in case studies doctors say that the adrenal gland will return to normal with time, but there is a % that wont. so now i have stopped the cream and was wondering if i take photolytic enznes it would help.
How can I buy some systemic
How can I buy some systemic Proleolytic Enzymes?
All our recommended formulas
All our recommended formulas are listed under the “Products” tab. For this one, you can find it here: http://www.baselinenutritionals.com/products/phi-zymes-90.php
Dear Jon
Dear Jon
You have a one little mistake in article: it’s not a Czech journal, but Slovak: Bratislavské Lekárske Listy
Bratislava is capital of Slovakia.
You are absolutely correct,
You are absolutely correct, and we have adjusted the article to reflect that fact.
Hello,
Hello,
Which much interest i read the above article about the enzymes. My partner has a serious blocked carotid artery, and there is not much they can do about it. We have tried serrapeptase without succes, and are really interested in using your product. He suffers from acid reflux, so that sounds like a good option. He also is diabetic (Type 2). Would there be any other supplements you advise? The company where i can order also doesn’t ship to France, is this not possible?
We forwarded your question to
We forwarded your question to Baseline Nutritionals since we do not sell any products at the Foundation. You may be interested in this article: http://www.jonbarron.org/article/sugar-metabolic-enhancement-formula-clinically-proven
Recently I read a new study
Recently I read a new study from Stanford University regarding Alzheimer’s Disease. In the article they stated: The researchers found that, in mice, blocking EP2 with a drug reversed memory loss and myriad other Alzheimer’s-like features in the animals.
My question is this: Does your Proteolytic Enzyme formula help remove the protein EP2 from the body, or do we need a drug to block EP2 specifically?
Microglia cells in our brains
Microglia cells in our brains are supposed to clear the brain of bacteria, viruses, and amyloid plaque build-up, stop working. They function well when people are young, but as we age, EP2 protein levels increase, which stops the microglia cells from operating efficiently. The connection to Alzheimer’s is that the microglial cells are tasked with constantly clearing amyloid-beta plaque from the brain, as well as keeping a lid on inflammation. If we lose that ability and things get out of control. A-beta builds up in the brain, inducing toxic inflammation.
There are no studies as yet that indicate that proteolytic enzymes clear EP2 from the brain, although there are indications they can reduce inflammation in the brain since they reduce inflammation systemically. Then again, no one has specifically looked for that effect in supplemental enzymes. However, there are studies that show that that certain bio-chemicals used in supplemental formulas such as l-carnosine at the very least mimic the effect of the microglial cells—that is clearing out beta amyloid plaque and working as neuro-protectors.
As I understand, fungal
As I understand, fungal protease and pancreatin are made from fungi. If a person is having a candida infection (gastrointestinal candida overgrowth) and is trying to get rid of it, is it alright to take phi-Zymes or should it be avoided?
And related to that, what is your recommendation on treating such a candida?
Thank you in advance
It’s very important to
It’s very important to understand that just because something is made from something doesn’t mean there is any of the original substance left in the final product. The purity level of the fungal enzymes used in supplements is generally so high (around 99.9%) that the original fungus is essentially undetectable through scientific analysis. It’s also worth noting, if you’re looking for something to worry about, that if you take anything with added vitamin B12, most B12 is made from genetically engineered bacteria—but again, none of the original bacteria remains.
I love science I am rellly
I love science I am rellly going to rethink my diet after reading this thanks for your research
where can I find the
where can I find the proteolytic enzyme wit these propeties you mention. I finding one with much less.
Here is one source: Http:/
Here is one source: http://Www.baselinenutritionals.com/Products/Phi-Zymes-450.Php
Can my husband take this if
Can my husband take this if he has fungus in toes…he has candida?
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe for specific medical conditions—merely provide information. With that in mind, I would read the articles we have on candida (search our site) and also read this: http://www.jonbarron.org/article/candida-natural-health-remedies. You can also rub a good anti-viral formula on the skin to kill fungus.
Jon,
Jon,
The more I research diet and health, the more I appreciate your brilliance! Your knowledge is amazing!
Best regards,
Walt
Thanks Walter!!
Thanks Walter!!
My 16 year old son suffers
My 16 year old son suffers from severe eczema. Right now, while the pollen is at its worst, he is going through a severe flare-up. He’s been through food allergy & intolerance testing and offending foods have been removed from his diet, but there has been little relief. Can you recommend any enzymes that would possibly be helpful for him? (Also, one of the foods he is allergic to is soy which is included in many supplements.) Any help would be immensely appreciated. Thank you!
Can the enzymes break down
Can the enzymes break down scar tissues in tendons? I’ve been dealing with Achilles tendinosis for years and now plantar faciitis, and I’m sure there’s some scar tissue there. I’ve been on a strict paleo diet for a week now (30 day gut cleanse) and am interested in enzymes if they might help.
Thanks!
Actually, are you familiar
Actually, are you familiar with platelet rich plasma injections for chronic tendinosis? If not, you might want to search it out on the web.
My grand sons both have
My grand sons both have sickle cell and it is caused by the shape of the cell . Can this help lessen or stop the severity of the episodes
Dr. Baron, I have used your P
Dr. Baron, I have used your P-Zymes for two years and I hold them significantly responsible for ending my recurring pneumonia and for reducing lung scar tissue. Thank you so much, my lungs now function so much better and there is no more chronic congestion. Meanwhile, my husband started taking the enzymes 2 weeks ago (4/day) in lieu of accepting warfarin as a blood thinner. However, he has also been taking two-2000 FU nattokinese tablets so now he’s taking around 4,500 FU’s of nattokinese daily. Might there be side effects (dizziness or?0 from this dosage?
Thanks again. If you would like a testimonial on the enzymes, I’m happy to write a special one!
Susan Maini
As Jon Barron frequently says
As Jon Barron frequently says, “Too much of a good thing is bad. No matter how healthy something is, if you overindulge in it, disease will result, not health.” If you take too many enzymes that inhibit clotting, then you can have an increased tendency to internal bleeding. One indication that you’re taking too much is an increased tendency to nose bleeds.
And yes, we would love to read a more detailed testimonial as to the results you’ve had on the pHi-Zymes.
I HAVE RA WILL PHI-ZYMRS HELP
I HAVE RA WILL PHI-ZYMRS HELP OR WOULD YOU SUGGEST SOMETHING ELSE.
THANK YOU
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe for specific medical conditions—merely provide information. With that in mind, perhaps you will find this article useful. http://www.jonbarron.org/article/rheumatoid-arthritis-and-seronegative-rheumatoid-arthritis
I just started a parasite
I just started a parasite cleanse, with the herbs taken 2X/day, 1/2 hour before a meal (so the bacteria are hungry to eat their poison). My gut is swiss cheese thanks to the parasites, & I haven’t eaten animal protein in months because they get into my blood, poison me, & cause anger/anxiety, etc. Are the enzymes something the parasites would enjoy eating? I’m already dehydrated, it can become unbearable if I take a serrapeptase or wobenzym (similar effect from anmal protein), and while I’d like to take regular doses of your enzymes to help with the die-off, I’m concerned it would feed the parasites: In which case, can I take them 1/2 hour after the parasite cleanse, then wait an hour to eat? Thanks.
Not sure what herbs you’re
Not sure what herbs you’re taking, but in general, parasites don’t “eat” the herbs. Anti-parasitic herbs such as wormwood, black walnut hulls, and garlic contain bio-chemicals that are toxic to the parasites. It is the bio-chemicals released by the herbs that kill the parasites. As for proteolytic enzymes, again, the parasites don’t eat them. The proteolytic action of the enzymes eats away at the protein component in the cell walls of the parasites, causing them to self-destruct.
Hi, my 18 year old daughter
Hi, my 18 year old daughter has just been diagnosed as being dairy intolerant (proteins,not lactose) would taking a protease enzyme help her. She is really struggling at the moment as dairy seems to be in everything.
Best piece I’ve ever read re
Best piece I’ve ever read re Proteolytics. I had bursitis in my left arm. Couldn’t raise it up w/o moderate pain. Health food store looked it up in the Balch book. I tried proteolytic enzymes. Aspirin or ibuprofen had not helped. 20 min later, pain was gone! I called my client’s health food store and told the assistant who had helped me placebo effect, he suggested. No way, I was a big.doubter!
They continued to work well.
Years later, getting on to the y lift at hunter west, my left leg slid on the ice mound that was often there. It’s been re-designed. Heard a pop and left leg went out from under me, with a warm feeling, in a very weak knee. Significant pain followed with the leg knee often giving away w/o warning. I found dr Keith McElroy, a brilliant orthopedic, head of surgery at Columbia Presbyterian, in NYC. Spent over an hour w me. Gave me a shot of a benign, non-lingering steroid. Said to come back if I needed another. Didn’t have to. Told me pain did NOT mean damage was being done. A low salt diet would help. It did. Keep the knee warm. Gave me a daypro scrip. On several occasions, I used the Proteolytics instead of daypro. Only lasted 4-5 hrs, but actually worked better at relieving the inflammation. Dr McElroy skiied at 88 yrs old.
I did use the Proteolytics numerous times after that, w varying results. Didn’t seem to work on muscular well. Better on tendons and ligaments. Mine was the acl. Tendinitis from what I’ve heard is often a sprained ligament. Tine to try yours!
This info is most helpful
This info is most helpful however no links to products or any products / brands suggested. I’m in Australia are there any products/brands you highly recommend that I can purchase?
All our recommended formulas
All our recommended formulas are listed under the “Products” tab. For this one, you can find it here: http://Www.baselinenutritionals.com/Products/Phi-Zymes-90.Php/
Hi,
Hi,
Is it possible to give proteolytic enzyme formula to cats? I have one male that is approx. 24 pounds and a female around 15 pounds. They recently caught parasites (round worms) and I’m looking for something natural. I use the Proteolytic formula myself and if it would help my cats, I can give them some as well.
Thank you.
Keep in mind that pets don’t
Keep in mind that pets don’t always respond to things in the same way that people do. Chocolate, for example, is poisonous to dogs. That said, if you’re talking about parasites, the Baseline formula that addresses that is the liver tincture. But again, that has not been tested for efficacy or safety with pets.
Would this be helpful in
Would this be helpful in treating the pain from chronic pancreatitis (essentially, inflammation of the pancreas)? I am already taking the digestive enzymes with meals for the pancreatitis. Also, do you know if this is safe to take during pregnancy? Thanks!
For obvious legal reasons, we
For obvious legal reasons, we can’t diagnose or prescribe for specific medical conditions—merely provide information.
With that said, there are studies that demonstrate some benefit in using supplemental proteolytic enzymes in dealing with pancreatitis, but obviously, the results would likely be different given different causes of the pancreatitis. And of course, if you are pregnant, you would want to run any supplements by your doctor before taking them.
And finally, you might find this link useful. http://www.jonbarron.org/article/pancreas-and-digestion
I can see from your answer
I can see from your answer earlier, I need to take both the proteolytic enzyme formula and a digestive enzyme, which product do you suggest I purchase; rhe CMIK-pH and what digestive enzyme? I will be ordering this now as I need something quick. I’m rapidly gaining weight because I don’t digest any food nor vitamins.
I can attest to the
I can attest to the information I just read in the “The Best Proteolytic Enzymes Formula | Barron Report”. Starting in 1999, I was working in the IT department of an Enzyme company out of Houston, TX. While typing information and reading material, I learned about Enzymes.
Since I received the Enzymes at cost, I began taking the maintenance dose and continued to supplement with Enzymes during meals until 2008. At the time, I did not recognize my underlying health issues, I just knew as a teen I became allergic to shellfish and around age 27 I appeared to become allergic to milk products. The Enzymes worked better than I knew at the time, because two years after stopping the use of any Enzymes (2010), my health began to decline slowly until Jan ’15 all systems crashed and I seemed overnight to be Allergic to all foods, all environmental triggers. Three months later I was rushed to the E.R. for the first time in my life.
At first, I did not correlate no longer supplementing with Enzymes, for the past years had any involvement in my health declining. I began purchasing basic Enzymes two month ago to use with food, until I can afford more to get back on a repetitive dose.
In retrospect, I should have known for two major reasons. First, my Grandfather, my Mother and myself all have issues with Sulfites/Sulfates and major sinus reactive allergies. Second, when I was still working at the Enzyme company, my Mother was diagnosed with Brest pre-cancer cyst and possible cancer. I talked with people at work and they suggested beginning her on Protease 375,000 and slowly work her up to a dose of 15 capsules a day. After, 3 months on the protocol, she returned from a check-up with a funny story. While the Technician and others began the scans, they had to stop to ask her a question. “You are here because of 22 cyst right?!?”after double checking their files, they had to inform her she did not have “Any” cyst in the new scans.
Stretch
Thank you for this wonderful
Thank you for this wonderful article, Jon!
Because of your article, I started looking into the papaya enzyme Papain, and I found on PubMed two research articles showing how a Papain diet suppresses and reduces cholesterol in mice and rabbit!
ncbi.nlm.nih.gov/pubmed/8780972
ncbi.nlm.nih.gov/pubmed/11185655
Fascinating topic!
Hello
Hello
Are proteolytic enzymes or enzymes in general harmful towards fertility and/or during pregnancy?
Certainly hope not since your
Thanks for all this
Thanks for all this information. I have a question for a friend, is it safe for nursing mothers take Proteolytic / Systemic enzymes?
Please see answer above to
Please see answer above to the same question.
Just wondering if you know if
Just wondering if you know if these enzymes have ever been specifically used on children with cystic fibrosis. My grandson is one and has this disease. Not sure if he is too young to try it. Or what the dose might be. If you have any information on others using it with this disease it would be helpful. Thanks
We have no information on
We have no information on children using it for cystic fibrosis.
I’m going to put this to the
I’m going to put this to the test with your formulas.
Can you direct me to a
Can you direct me to a product that will help eliminate dental plaque? Is there a possibility of reversing gum disease?
The bottom of this article
The bottom of this article gives some great suggestions: https://jonbarron.org/article/gum-disease-forest-not-trees
Question re: absorption.
Question re: absorption.
A segment of my ascending colon and a portion of my ileum we’re used to create a substitute bladder (Indiana Pouch). As a result, I must take certain supplements (B12, D3) subligually to overcome the resulting absorption issue associated with the loss of a part of my small intestines.
What guidance can you offer regarding my ability to effectively absorb a systemic enzyme product and any options to facilitate the process despite my situation?
Thank you
As you will have noticed in
As you will have noticed in the article above, systemic enzymes are absorbed in the small intestine, well before they reach the ileum and colon.
I have Ulcerative Colitis in
I have Ulcerative Colitis in “remission” from the immune suppressant 6-Mercaptopurine. I have been taking pHi-Zymes for about 45 days. I feel phenomenal—the best in 30 years. I just got a C-Reactive Protein result of 0.4! Only half of my best ever. I think your systemic enzymes are the reason.
One question, is there any reason pHi-Zymes would be a conflict with the immune suppressant? I can’t think of any.
Thanks for a great remedy.
Thank you for sharing your
Thank you for sharing your great results! In answer to your question, pHi-Zymes would not likely present a “direct” conflict with immune suppressant drugs. Theoretically, though, it might (possibly, maybe) present an “indirect” conflict under the following scenario.
The bottom line is that this scenario is purely hypothetical. In the 14 years that pHi-Zymes has been available, this is the first time that anyone has informed us that they are using pHi-Zymes while using immunosuppressants. Please keep us informed of how it’s working for you as this can be shared with anyone who might follow in your footsteps.
PS: Your CRP results are certainly in line with what might be expected considering the ability of proteolytic enzymes to control inflammation systemically.
As a 68 year old British
As a 68 year old British woman with increasingly debilitating osteoarthritis, I take a lot of supplements and avoid pharmaceutical remedies. I find Jon Barron articles and explanations very illuminating and have recently started on digestive enzymes to help with IBS, which I have managed for years with healthier food choices. My query is I can only use the guidelines he offers for his supplements as the products are not available in the UK, unfortunately. Shipping costs are prohibitive, and I wonder if you have a UK distributor in place or would be planning to, to help your overseas devotees have ready access to the best formulas at reasonable cost.
You have options! However,
You have options! However, the Foundation does not sell any products. We are purely a non-profit, online health information service only. All of Jon Barron’s formulas are sold by http://www.baselinenutritionals.com. Any customer or product related questions need to be directed to: [email protected].
Where do I purchase this?
Where do I purchase this?
The Foundation does not sell
The Foundation does not sell any products. We are purely a non-profit, online health information service only. All of Jon Barron’s formulas are sold by http://www.baselinenutritionals.com. Any customer or product related questions need to be directed to: [email protected].
My girlfriend had a collapsed
My girlfriend had a collapsed lung around 2 years ago and still has some occasional pain which the doctor ascribes to scar tissue from her operation. I am considering giving some phi-zymes to my girlfriend to dissolve the scar tissue. Is there any risk the enzymes will also dissolve the (non living) glue that was used to attach her lung back to her chest wall ?
I am confused about
I am confused about purchasing the best proteolytic enzymes for treating inflammation. Do you recommend any specific brands? I wish to try this but don’t want to waste money and effort on inferiot products.
All of Jon’s recommended
All of Jon’s recommended formulas are listed under the “Products” tab. For this one, you can find it here: http://Www.baselinenutritionals.com/Products/Phi-Zymes-90.Php/
Can dogs take proteolytic
Can dogs take proteolytic enzymes? There are no enzymes in dog food. If yes, what might be the doseage for a 90 pound Labrador? Thank you for a great supplement which I have recently started taking.
Hi I suffer from SIBO would
Hi I suffer from SIBO would these enzymes help I usually use hydrochloric tablets. With thanks
For obvious legal reasons, we
For obvious legal reasons, we cannot diagnose or prescribe. That said, SIBO is, by definition, a form of dysbiosis—an overgrowth of bacteria where they don’t belong. In this case, we’re talking about an overgrowth of bacteria in the small intestine. In a healthy small intestine, you will have beneficial bacteria, just in much smaller numbers and different strains than will be found in the large intestine. With SIBO you have overgrowth, and even if those are beneficial bacteria, an overgrowth is an overgrowth—it’s dysbiosis. The trick in dealing with SIBO is use herbs to help bring down the overgrowth, and then use probiotics—in very small amounts—to slowly but methodically rebalance the small intestine with the right strains and the right numbers. Work with an alternative health practitioner.
I am in dire need of using
I am in dire need of using the pHi-Zymes supplement to assist my circulatory system due to PAD…especially in my feet. I also have scar tissue I need removed. My concern is the umbilical hernia mesh I have in place. I’ve been searching high and low for this answer, but haven’t had any success. Jon’s expertise in this area is much needed. Will the enzymes adversely affect the mesh and cause problems down the road if I use them? I know there has to be scar tissue involved with the mesh.If the enzymes were to cause problems in this area due to the mesh, is there an alternative to removing plaque from the blood vessels in my feet that can aid in the removal of plaque build up in my circulatory system? Would another option be Nattokinase used by itself, or possibly another option? I hope you can help me with this, so I can get started as soon as possible. Thank you in advance.
Going to give it a try. Had
Going to give it a try. Had planned on getting enzymes that had Serrapeptase for it’s ability to eliminate Fibrin which I believe is one of the major health culprits, but you seemed to have that covered.
Where can I buy the
Where can I buy the proteolytic enzymes?
Thank you
All of Jon’s recommended
All of Jon’s recommended formulas are listed under the “Products” tab. For this one, you can find it here: http://Www.baselinenutritionals.com/Products/Phi-Zymes-90.Php/
Good but which is the best
Good but which is the best proteolytic enzyme to purchase
All of Jon’s recommended
All of Jon’s recommended formulas are listed under the “Products” tab. For this one, you can find it here: http://Www.baselinenutritionals.com/Products/Phi-Zymes-90.Php/
Hello,
Hello,
I enjoyed reading your article. I’ve have had RA for 19 years. I am 62. My problem is that I am extremely sensitive to a lot of foods, and more specifically, to seasonings or herbs. If I eat a prepared food, the seasonings that it was prepared with will cause me joint pain, specifically in my hands/arms. Everything seems to bother me: cayenne, turmeric, cumin, oregano, arugula, red pepper, etc. The only few things I can prepare my food with is garlic powder, onion powder, salt, and black pepper. That’s it! And it’s not a good idea for me to use salt at all because I swell very easily.
But my point is that your blood cleaner sounds great, but there is no way I could tolerate it because of the herbs in it.
I have no doubt that I have leaky gut. I’ve been taking meds like prednisone, plaquenil, arava, Enbrel, etc for 19 years, however, I’m off of prednisone and plaquenil now as of last February, but that’s still a long time having to take it.
I was wondering if you have any suggestions or have you heard of anyone with really bad sensitivities to the point where they are extremely limited in what they eat? And what’s making me miserable is that I’m ALWAYS HUNGRY! To have a limited diet and always hungry, always craving salty/sweet foods is making me miserable. Thankfully, I don’t have and have never had a weight problem (5’4″, 110 lbs). BTW, I turned vegan about six years ago, however, I’ve been going back and forth a little, sometimes eating a little chicken or beef. But I will don’t have any intentions of going back to dairy or pork at all.
Well, thanks for listening,or reading!
Cynthia