Naturally Improve Blood Sugar Levels, Reversing Diabetes Program | Barron Report

Date: 04/01/2005    Written by: Jon Barron

Diabetes, Cholesterol, Blood Pressure and Life Extension

In the summer of 2002, I developed a sugar/lipid metabolic enhancement formula. Although extremely valuable for diabetics, this formula was actually designed to smooth out the metabolic "spikes" that come when any of us eats high-glycemic foods. Since its release, I've continued to refine the formula, to enhance its effectiveness. After playing with hundreds of variations, that goal has been accomplished.

Once you begin to explore the world of herbs and supplements that theoretically ameliorate the symptoms of bad diet, you soon discover that there are literally dozens and dozens of them. But after experimenting for a number of months with all of them, you learn that you can focus on a combination of just four. The value of this particular combination lies in the fact that each of the ingredients addresses the key problems through entirely different mechanisms -- thus not just duplicating each other's benefits, but actually complementing and amplifying them. The bottom line is that it becomes quickly evident that the effect of this combination is far greater than the sum of its parts (as significant as that sum is).

Unfortunately, figuring out what ratio to use when combining these ingredients is not easy since there is no historical data using this combination, and there are no studies to base any decisions on. That leaves only one alternative -- trial and error with multiple variations, combined with rigorous testing. After months of playing with the formula and months of tweaking, optimum ratios were determined.

My original formula was based on the following four ingredients:

  • Nopal cactus
  • Konjac mannan
  • Gymnema sylvestre
  • High galactomannan fenugreek extract

Let's look at the ingredients individually.

Nopal Cactus -- 300 mg

Nopal (Optunia) is native to the southwestern desert regions of the United States and Mexico and has a whole range of health benefits (all proven in numerous studies, both animal and human). These include the ability to:

  • Lower blood sugar levels by blocking absorption of sugar in the intestinal tract. 1, 2, 3, 4
  • Lower overall cholesterol levels, improve the ratio of HDL to LDL cholesterol, and lower triglycerides by preventing the conversion of blood sugar into fat and by eliminating excess bile acids, which would ultimately be converted into cholesterol.5, 6
  • Lower blood pressure.7
  • Induce weight-loss by curbing appetite and facilitate the breakdown and excretion of fat.8
  • Prevent ulcers.9
  • Protect the liver against multiple toxins.10, 11
  • Block the absorption of fat.12

Konjac Mannan -- 234 mg

Like nopal, konjac mannan (glucomannan) benefits the human body in numerous ways. Studies have shown that it can:

  • Lower blood sugar levels by ameliorating insulin resistance.13
  • Improve cholesterol profiles by binding to cholesterol and removing it as waste.14, 15
  • Dramatically lower triglycerides.16
  • Lower blood pressure in a matter of weeks.16
  • Reduce constipation in as little as three days.17
  • Help people lose weight and then keep that weight off (significant weight-loss for about 10 weeks, followed by indefinite stabilization).18

Fenugreek -- 192 mg

As far back as ancient Egypt, fenugreek (Trigonella foenum-graecum) was prized for its healing properties. However, its strong bitter taste and its tendency to produce strong odors in sweat and urine made it less than optimal as a substantial component of any formula. A few years ago, however, a tasteless, odorless fenugreek extract with a 60-80% galactomannan content was developed. This allows access to all of fenugreek's benefits, with none of the downside. Benefits include:

  • Decreasing the glycemic incidence of food. In studies, the unique galactomannan ratio of galactose and mannose in fenugreek reduced urinary sugar levels of participants by as much as 54%.19
  • Decreasing insulin response to food and helping maintain normal serum glucose levels by slowing down the absorption rate of carbohydrates, thereby lowering insulin requirements.20
  • Inhibiting the absorption of fats. (The steroidal saponins in fenugreek account for many of its beneficial effects, particularly the inhibition of cholesterol absorption and synthesis.)21
  • Aiding in weight-loss by increasing the sense of fullness.22

Gymnema sylvestre -- 192 mg

Gymnema may be the classic "anti-sugar" herb. In India, its name literally means "The Sugar Destroyer." Gymnema offers several unique benefits in this formula.

  • It significantly reduces the metabolic effects of sugar by preventing the intestines from absorbing the sugar molecules during the process of digestion, and it accomplishes this through a different mechanism than any of the other ingredients in the formula. The active molecule in gymnema, gymnemic acid, works by "filling" the sugar receptor sites in the intestine -- making them unavailable to ingested sugars.23
  • It reduces the symptoms of glycosuria (sugar in the urine).24
  • It stimulates the insulin secretion of the pancreas.25
  • Even better, It has been shown to regenerate the islets of Langerhans in the pancreas, especially the beta cells. In tests on diabetic rats, the pancreas doubled in size and grew new insulin-producing cells. This is very significant. Nothing else does this.26
  • Over time, it reduces the taste for sugar in much the same way that it prevents absorption in the intestine. The gymnemic acid blocks the receptor sites of the taste buds. (In fact, put some on your tongue, and it will kill all taste for sugar for a couple of hours.)27, 28

Testing the Effect

When it was first created back in 2002, there were a number of medical doctors who volunteered to test the formula with their patients. Over a period of about 6 months, the results were nothing short of miraculous. (Note: for these studies, the only change the patients made was to take the supplement.)

Blood Sugar

There are two things that are important to understand. First, without the rest of the Baseline of Health® program being utilized, we are merely managing symptoms here. As long as this natural supplement is used, the symptoms may be moderated, but the underlying condition is unlikely to be resolved if the whole program is not instituted--including dietary changes. Below is a graph showing the blood sugar levels of a typical participant in the study over a period of about six weeks.

The graph shows an astounding drop of almost 500 points in just two weeks. The little hiccup resulted from the individual not using the formula for a day while at the same time indulging in sweets. The next day, when the formula was resumed, the sugar levels once again returned to normal. (This is a good example of why you really want to incorporate the rest of the Baseline of Health Program while using the supplement--to address the underlying condition.) Other examples include patients dropping from 387 to 82 and from 488 to the mid-80s.

The bottom line is that when used as directed, this natural formula absolutely dropped dangerous blood sugar levels into the normal range for many participants. (We'll talk more later about why some participants did not achieve the desired results and how they were able to resolve that.)

There is also another test, the A1c test, which shows the average amount of sugar (glucose) that has been in your blood over the last 2 or 3 months. It does this by measuring the amount of glucose that's attached to your red blood cells. The higher the level of your blood sugar, the more sugar will be attached to your red blood cells. The glucose stays attached to the hemoglobin for the life of the red blood cell, which is about 2 or 3 months. Therefore, A1c test results give a picture of how much glucose has been in your bloodstream during the past 2 or 3 months. On the formula, we watched many people drop from severe diabetic (9.0) to totally non-diabetic (5.7) in under six weeks. This is unprecedented.

Cholesterol

Cholesterol is often overrated as a factor in heart disease. In truth, it's guilty by being found at the scene of the crime, not for actually committing the crime itself. However, it is an indicator of other problems in the body--a canary in the coal mine if you will; and there is no question that it thickens the blood, which when combined with narrowed arteries, is a very real risk to the heart and brain.

The bigger problem is that standard prescription medications (statin drugs) damage the one organ in the body, the liver, that's actually responsible for regulating cholesterol. The long term implications of this approach are not good. On the other hand, to be able to regulate cholesterol while truly supporting the liver would be a miracle.

When people were on the formula, we saw consistent downward trends in total overall cholesterol levels, and more importantly, consistent improvement in the LDL/HDL ratios (from 4 to 2.3 in just 3 weeks, for example) -- all while helping rebuild the liver.

Triglycerides

We also saw consistent downward trends in triglyceride levels.

Blood Pressure

Blood pressure dropped enough for several patients to discontinue their blood pressure medication--with their physician's guidance.

Weight

Weight-loss in the range of 5-8 lbs during the study. (Again, with no change in diet.)

Immune System

Although nothing in the formula directly affects the immune system, the formula will, nevertheless, profoundly benefit that system. Since the intake of large amounts of high-glycemic carbohydrates plays havoc with the immune system, preventing the absorption of those carbohydrates will dramatically enhance most people's natural immune functions.

Does it Work for Everyone?

No. Many of the people suffering from blood sugar problems, and particularly senior citizens, also lack sufficient stomach acid to break capsules down in a timely manner. For those people, we found that if they take the formula out of the capsules and drink it down mixed with a little water, they start to see results. Also, keep in mind that this formula will not mask your symptoms like other products often do. Instead, by using the formula as suggested, it is supporting your body's ability to correct the underlying problem. It may take 30-40 days, or even more in some cases for you to begin to see significantly positive results. Results are likely to be quicker and more pronounced if the entire Baseline of Health Program is implemented.

Warning

After months of testing, the doctors involved issued two warnings.

  • Anyone under a doctor's care for diabetes, high cholesterol, or high blood pressure must use this supplement only with their doctor's permission and guidance since it is extremely likely that it will require changes in their medication.
  • It is essential that you use this supplement with food (ideally about 5-10 minutes before eating). If you do not eat when using the formula, you may see your blood sugar levels crash. If you experience such a crash, simply eat some food to move your blood sugar levels back up to normal in a matter of minutes.

Changes to the Formula

Given time over the next several years and the ability to test several hundred more variations, three additions to the formula were implemented that significantly enhanced its effectiveness. Note: the reason it requires so much testing is that the problem lies not just in finding new ingredients and adding them, but in finding the right sources of those ingredients and determining the exact amounts to add without diminishing the effectiveness of the original ingredients. You can't just slam it together based on something you read in an herb book and expect it to work.

1% Corisolic Acid from Banaba Leaf -- 16 mg

The blood sugar regulating properties of corosolic acid, the active ingredient in banaba leaf (Lagerstroemia speciosa), have been demonstrated in cell culture, animal and human studies. In isolated cells, it is known to stimulate glucose uptake.29 In diabetic mice, rats, and rabbits, banaba feeding reduces elevated blood sugar and insulin levels to normal. In humans with type II diabetes, banaba extract, at a dose of 32-48 mg per day for as little as two weeks, has been shown to be effective in reducing blood sugar levels by as much as 30% and maintaining tighter control of blood sugar fluctuations.30 An interesting "side-effect" of tighter control of blood sugar and insulin levels is a significant tendency of banaba to promote weight loss (an average of 2-4 lbs. per month) -- without significant dietary alterations.31 It is likely that modulation of glucose and insulin levels reduces total caloric intake somewhat and encourages moderate weight-loss.

Bitter Melon -- 66 mg

At least three different groups of constituents in bitter melon (Momordica charantia) have been reported to have blood-sugar lowering actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids. It is still unclear which of these is most effective, or if all three work together. Already, some clinical trials have confirmed the benefit of bitter melon for people with diabetes.32, 33, 34

Early studies suggest that one of the components of bitter melon extract may be effective in slowing the growth or spread of some types of cancer, particularly breast cancer.35 Cervical cancer patients (stage II or III) have shown some evidence of immune system response to bitter melon while undergoing radiotherapy.36

Some studies suggest that a component of bitter melon seeds may provide benefits for HIV by preventing the virus from infecting human cells. However, these studies have been conducted only in laboratory settings, and no research has been done in humans.37

Note: There is some evidence that couples looking to conceive should not use bitter melon. One study in particular showed that bitter melon may have antispermatogenic activity, at least in rats.38 The study is far from conclusive, and even if true for humans, the results require extremely high levels of bitter melon and are temporary -- with speratogenic activity quickly returning to normal upon ceasing ingestion.

Cinnulin PF® -- 100 mg

Cinnulin PF is a water soluble polyphenol Type A polymer that is the only cinnamon extract validated in studies by the USDA to:

  • Improve your body's insulin response up to twentyfold.39

Cinnulin is up to 700% more effective than cinnamon itself and avoids the potentially harmful allergic side effects that can occur when using high doses of cinnamon. In fact, a 2006 study found that 83% of those given the Cinnulin PF active Type A Polymer extract experienced an average 8.4% drop in blood sugar, compared to only 33% of those in the placebo group.40 Moreover, subjects additionally showed statistically lower body fat, enhanced lean body mass, lower systolic blood pressure, and saw improvements in various antioxidant measures

Other studies have demonstrated that these same polymers are both effective mimetics of insulin in vitro as well as insulin potentiators.41 The bottom line is that Cinnulin PF helps metabolic syndrome factors by supporting healthy glucose levels, body composition, and blood pressure in both challenged individuals looking to get better and healthy individuals looking to remain that way.

Life Extension

As it turns out, this formula may also have the ability to extend life. How?

The role of insulin in the aging process is becoming more and more apparent as new research becomes available. For example, Brown University scientists published a study in 2013 concluding that insulin played a "central role" in aging.42 According to the study, when the chemical messages sent by an insulin-like hormone are reduced inside the fat cells of a fruit fly, the fly's lifespan increases significantly, by an average of 50%. Fruit flies are notoriously short-lived but the researchers have begun to understand why some fruit flies live longer than others. They documented a direct association between insulin and life span, tracing an insulin signaling cascade through to protein quality control in muscle tissue and shortened life span, which may have broad implications across species.

The recent Brown University experiments shed important light on the role insulin plays in the regulation of its own synthesis. The study shows that if you block the hormone's action inside a few specific cells, the entire body stays healthier longer. Scientists previously thought insulin triggered other hormones to achieve this effect, but lead researcher Marc Tatar and his team found that insulin regulates its own production and that it directly regulates tissue aging. Bottom line: keep insulin levels low and cells are stronger, better able to fight off infection and age-related diseases such as cancer, dementia, and stroke.

As Tatar said when talking about an earlier 2004 study, "Think of the body like a car. We knew insulin controlled the car's speed by regulating things like the gas pedal and the fuel injectors. Now we know that insulin is also the fuel that makes the engine go."43

To conduct the 2004 experiment, Tatar and four other Brown researchers created a line of genetically altered flies which had dFOXO -- a protein controlled by the fly equivalent of insulin -- inserted into the genetic material of fat cells near their brains. Some flies were fed mifepristone, a chemical copy of progesterone. This hormone activated a switch attached to dFOXO, which in turn repressed the normal insulin signals inside the cells. As a surprising result, insulin production was lowered throughout the body. These flies lived an average of 50 days -- 18 days longer than flies whose insulin signals went unchecked.44

"We now know that insulin is a direct player in the aging process," Tatar says. "So the research fits some key puzzle pieces together. And it should change the way we think about aging."

In contrast to the other hormones of aging that decline as we get older and cause manifestations of the aging process through their lower levels, circulating insulin levels actually increase in many individuals as they age. This occurs because the tissues that respond to insulin to lower blood sugar levels (liver, muscle, and fat cells) become resistant to its action. This in turn leads the pancreas to secrete more and more insulin in an attempt to keep the blood sugar at a normal level. This is sometimes called the pseudo-diabetes of aging.

A higher circulating level of insulin sets into motion a cascade of damaging effects:

  • The cells lining the arteries produce higher levels of clotting factors--increasing the risk of a heart attack.
  • Fat is accumulated, particularly in the abdominal region, which in turn makes the tissues more insulin resistant.
  • The higher blood sugar levels increase the accumulation of Advanced Glycation End Products which can destroy proteins.
    break down organs, and stiffen connective tissue.
  • High insulin levels have also been linked to a higher incidence of certain cancers.

If these levels remain high enough for a long enough period of time, they can kill the insulin producing cells in the pancreas and cause overt diabetes.

Bottom line: A major focus of any anti-aging program is to keep insulin levels in a low normal range.

So where do we go from here?

  • Metformin, the diabetes drug used to reduce insulin levels, is certainly an option, and although as far as drugs go, metformin is relatively benign, it is not totally without side effects. It occasionally causes death from lactic acidosis, for example, which is not insignificant for those who die.45  
  • But more importantly, it is quite likely that some minor changes in lifestyle and the use of natural supplements can offer the same benefits with no negative side effects and at less cost.

What Can We Do

Cut way back on your use of refined carbohydrates. In Lessons from the Miracle Doctors, I identified refined carbohydrates as the number two killer in the diet after synthetic trans fats. It now seems they may rank as the number one controllable aging factor. If you find that you are actually addicted to grains and sugars and can't cut back, you might want to check out Dr. Joseph Mercola's book, The No-Grain Diet, which will provide a pathway for cutting back on your grains and sugars. Bottom line, move your diet away from refined grains and sugars to one that consists of complex carbohydrates found in most vegetables (but not potatoes), proteins, and natural fats (avoiding refined oils and hydrogenated oils). Fresh fruits are okay in moderation, but absolutely unacceptable in processed form (as found in pastries and jellies, etc.) and unacceptable as found in bottled juices.

Do a fresh vegetable juice fast one or two days a week. I've always recommended doing just that for its health benefits in cleaning out the body; but as it turns out, it also has significant longevity benefits. As Scientific American points out, "Intermittent fasting, which includes everything from periodic multiday fasts to skipping a meal or two on certain days of the week, may promote some of the same health benefits that uninterrupted calorie restriction promises."46  

Use natural glucoregulatory herbs with your meals. These include herbs such as:

  • Nopal cactus
  • Konjac mannan
  • Gymnema sylvestre
  • High galactomannan fenugreek extract
  • Banaba leaf extract
  • Bitter melon extract
  • Water soluble polyphenol Type A polymer cinnamon extract

The use of these herbal extracts will significantly reduce the amount of simple carbs your body absorbs, and minimize the insulin response from those that get through. In effect, they will mimic the effect of metformin, without the side effects. This was one of the prime reasons for which I created this formula. In addition:

  • Use a full spectrum antioxidant formula to minimize the destructive aging impact of free radicals produced in the body.
  • Use an L-carnosine based formula such as Ever Young™ to minimize the impact of Advanced Glycation End Products which can destroy proteins, break down organs, and stiffen connective tissue.
  • Consider using an all-natural progesterone crème (women's or men's) to help throttle back insulin production in the body.
  • Use a hormonal balancing formula to free up bound testosterone.

One final note. It's never too late to start. In fact, many of the major benefits can be received in as little as four weeks on the program. This formula is not just for people suffering from sugar challenges. Everyone can benefit with regular use.

 

(Originally published 04/01/2005. Updated 01/09/2015.)

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  • 41. Anderson RA, Broadhurst CL, et al. "Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity." J Agric Food Chem. 2004 Jan 14;52(1):65-70. http://www.ncbi.nlm.nih.gov/pubmed/14709014
  • 42. Bai H, Kang P, Hernandez AM, Tatar M. "Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila." PLoS Genet. 2013 Nov;9(11):e1003941 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820802/
  • 43. The News Service. "Insulin plays central role in aging, Brown scientists discover." Brown. June 2, 2004. (Accessed 8 Jan 2015.) http://www.brown.edu/Administration/News_Bureau/2003-04/03-149.html
  • 44. Hwangbo DS, Gersham B, Tatar M, et al. "Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body." Nature 429, 562-566 (3 June 2004). http://www.nature.com/nature/journal/v429/n6991/full/nature02549.html
  • 45. Manes M, Pellu V, Caputo D, et al. "Metformin- related lactic acidosis." G Ital Nefrol. 2014 Nov-Dec;31(6). pii: gin/31.6.7. http://www.ncbi.nlm.nih.gov/pubmed/25504165
  • 46. David Stipp. "How Intermittent Fasting Might Help You Live a Longer and Healthier Life." Scientific American Volume 308, Issue 1. (Accessed 9 Jan 2015.) http://www.scientificamerican.com/article/how-intermittent-fasting-might-help-you-live-longer-healthier-life/

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Comments

  •  
    Submitted by Guest on
    June 18, 2011 - 11:15pm

    Hi, I am new to this. How do I find out more about the formulations referred to in this article for nopal, konjac mannan, fenugreek, gymnema sylvestre, corosolic acid, and bitter melon?
    My daughter has a need for this.
    Thank you,
    Debbie Knight

  •  
    Submitted by BaselineFoundation on
    August 10, 2011 - 1:13pm

    Hi Debbie,

    Please got to the link at top where it says "Products" and you can scroll down to see all of Jon Barron's recommended formulas, and who sells them.  You may want to check out "sugar metabolizer."

    Thanks!

  •  
    Submitted by Bonny on
    April 7, 2012 - 6:28pm

    I would like to order this as I use Nopala but am not sure what the product name is. Thanks

  •  
    Submitted by BaselineFoundation on
    April 11, 2012 - 2:12pm

    Hi Bonny,

    See my response above your comment.  

  •  
    Submitted by Becky on
    December 14, 2011 - 8:35am

    I have been taking the Nopal Cactus suppliment for 4 months. My cholesterol decreased 28 points, LDL decreased 16 points and Triglycerides went down 39 points. I also do not have the aches and pains I was feeling prior to taking the supplement. I also lost 8 pounds.

    My dctor is extatic with the results. I didn't see a decrease with my A1C, it went up .1 and I had a decrease in my HDL by 4 points but I am starting a more active exercise program.

    I think this stuff is a winner. I cannot take any statin drugs and this is the first thing that has touched any of my readings;I never saw this much change when I stopped eating red meat!

  •  
    Submitted by EB on
    March 12, 2012 - 10:47am

    Hi Jon we have used your products for about 15 years now and have had marvelous results. The nopal has done the following:

    * Have been off codeine, flexeril, tramadol, etc.. due to neck surgery and if I didn't use them I was in horrible pain but the nopal removes all inflammation and no more drugs needed and no pain.
    * Drastically helped with sleep apnea as it removed inflammation of throat too and allows person to breathe and not wake up constantly. The LOUD snoring is also gone.
    * Blood pressure has dropped to 110/72
    * My cholesterol total was 230 and is now 163 and the LDL 113 HDL 50 and triglycerides 103. For 60 years of age those are awesome.
    * Hemoglobin A1C is 5.1 as below 6. is awesome.
    * Several people I know have eliminated surgery, gotten rid of canes
    and walkers and more importantly pain simply by using the nopal
    products
    I met you at a Changes/Healing America convention and your work is beyond awesome.
    *Thanks and keep up the great work you do.

  •  
    Submitted by William Dawidowski on
    July 30, 2012 - 8:10am

    I see that there are outstanding results from using the Nopal Cactus as a single supplement. Is it correct that it has the potential, as a stand-alone supplement, to lower cholestrol/triglyceride levels? I do not have any particular worries about diabetes but would like to consider the benenefits of the Nopal Cactus as a single additional supplement. Thanks

  •  
    Submitted by BaselineFoundation on
    July 30, 2012 - 2:29pm

    Maybe this will help. http://www.ncbi.nlm.nih.gov/pubmed/10347696

  •  
    Submitted by Sean McFarlane on
    February 3, 2013 - 2:22am

    Hi, I live in the uk and have always showed an interest in curing my type 2 diabetes of 14 years. My doctor says its a lifetime disease which I struggle with as I think different.
    My only issue is how to make a safe switch from metformin to these natural products. Also do you run a clinic as I would be more than happy to come to the u.s to be educated more about these findings. Thanking you in advance for your response.

  •  
    Submitted by VickieBerry on
    July 24, 2013 - 12:01pm

    I can't seem to get my sugar under control.This noting it was 400 So I ask the doctor to put me in the hospital and she said no.I do not want to die this way or lose my eyesight or kindness fuctions.Please help me

  •  
    Submitted by BaselineFoundation on
    July 25, 2013 - 5:55pm

    Hi Vickie,

    Reading this article is a step in the right direction!

  •  
    Submitted by Anwar on
    August 31, 2013 - 11:57pm

    After high profile recommendations i purchased Glucotor 2
    now this new product, Could you tell us what'she difference ?

    regards

  •  
    Submitted by BaselineFoundation on
    September 2, 2013 - 2:20pm

    The latest version of Jon Barron's formula is sold by Baseline Nutritionals called Glucotor v2.  Sounds like that is what you purchased.

  •  
    Submitted by JOHN B on
    December 22, 2013 - 2:43pm

    If heart health can be restored by natural supplements why on earth are invasive operations such a valve replacement regularly used.

    We are given a body often capable of self healing - let us learn to use this ability and avoid a lifetime on drugs

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