Mouth Bacteria Linked to Pancreatic Cancer | Natural Health Blog

Date: 05/03/2016    Written by: Beth Levine

Oral Bacteria Linked to Pancreatic Cancer

Mouth Bacteria Linked to Pancreatic Cancer | Natural Health Blog

No matter how good your oral hygiene is, you've got lots of bacteria in your mouth. And that's not a bad thing. Some of these bacteria are actually beneficial, helping to break down the foods you eat and aid in digestion. But other organisms can be detrimental to your health, and not just by promoting gum disease and tooth decay. New research suggests that certain forms of oral bacteria may be associated with a greater likelihood of pancreatic cancer.

Phi-Zymes from Baseline Nutritionals

The study, which was conducted at the NYU Langone Medical Center's Laura and Isaac Permutter Cancer Center in New York, New York, found that the presence of two specific bacteria in the mouth may indicate an elevated risk of developing pancreatic cancer over time.1 The subjects were 140,000 healthy men and women who had provided oral wash samples to the National Cancer Institute and the American Cancer Society for use in long-term cancer risk investigations. These volunteers were tracked for a 10-year period, during which time 361 were diagnosed with pancreatic cancer.

The scientists then analyzed the samples from the 361 participants with pancreatic cancer as well as the samples from 371 of the participants who did not get the disease to compare similarities and differences in the types of bacteria found. There were two forms of oral bacteria notably more prevalent in the subjects with pancreatic cancer. Those who carried high levels of Porphyromonas gingivalis were determined to have a 59 percent increased risk of pancreatic cancer, and those with a greater presence of Aggregatibacter actinomycetemcomitans were shown to have a 50 percent higher risk of developing pancreatic cancer.

While the study was not designed to prove cause and effect, it does show a significant link between the existence of these particular bacteria in the mouth in larger numbers and an elevated likelihood of receiving a pancreatic cancer diagnosis. The research was somewhat limited by the small number of participants included, however, and would benefit from being performed again on a much larger scale.

Despite that, though, the findings are in line with earlier studies that showed these two types of oral bacteria are tied to other kinds of health issues. A 1998 study at Ohio State University in Columbus found that the presence of Porphyromonas gingivalis in the mouth may increase the risk of periodontitis, a progressive condition that often results in tooth loss.2 Similary, a 1988 study at the University of Pennsylvania in Philadelphia discovered that Aggregatibacter actinomycetemcomitans was a factor in periodontal disease.3

Periodontal health issues might seem a little more of an obvious connection, since it would be reasonable to think that oral bacteria would influence the area in which they are located more so than other parts of the body. But when you think about it, the pancreas is part of the digestive system, so it certainly stands to reason that harmful germs can make their way from the mouth to the pancreas and cause damage there as well. In addition, if the bacteria lead to periodontitis, then they would have direct access to the bloodstream and the pancreas through the infected tissue in the mouth--not to mention direct access to the lungs as bacteria in the mouth and throat are easily inhaled when breathing. And a 2007 study at the Harvard School of Public Health in Boston, Massachusetts showed that men with periodontal disease and tooth loss appear to be at greater risk for developing pancreatic cancer.4

We obviously do not have complete control over which bacteria take up residence in our mouths. However, we can positively influence our oral bacteria colonies by brushing and flossing thoroughly every day, eating a more nutritious diet, supplementing with proteolytic enzymes, and even oil pulling may help. It's certainly in our best interest to do whatever we can to lessen our chances of developing pancreatic cancer, since this disease typically kills more than 95 percent of patients within five years of their diagnosis.

And of course, one of the major risk factors for pancreatic cancer is smoking, so if you are still addicted to tobacco, you need to quit. In fact, smoking may well be linked to the existence of the problem strains of bacteria in your mouth: A 2016 study by the same team of researchers as the current trial discovered major differences in the amount and combination of oral bacteria in the oral microbiomes of smokers.5

  • 1. Ahn, Jiyoung; et al. "Certain Oral Bacteria Associated With Increased Pancreatic Cancer Risk." American Association for Cancer Research. 19 April 2016. Accessed 24 April 2016. http://www.aacr.org/Newsroom/Pages/News-Release-Detail.aspx?ItemID=876
  • 2. Griffen, Ann L.; et al. "Prevalence of Porphyromonas gingivalis and Periodontal Health Status." Journal of Clinical Microbiology. November 1998. Accessed 25 April 2016. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC105308/
  • 3. Slots, Jergen and Listgarten, Max A. "Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases." Journal of Clinical Periodontology. February 1988. Accessed 25 April 2016. http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.1988.tb00999.x/full
  • 4. Michaud, Dominique S.; et al. "A Prospective Study of Periodontal Disease and Pancreatic Cancer in US Male Health Professionals." Journal of the National Cancer Institute. January 2007. Accessed 25 April 2016. http://jnci.oxfordjournals.org/content/99/2/171.abstract
  • 5. Wu, Jing; et al. "Cigarette smoking and the oral microbiome in a large study of American adults." The ISME Journal. 25 March 2016. Accessed 25 April 2016. http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej201637a.html
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Comments

  •  
    Submitted by Cheryl Aubuchon on
    May 10, 2016 - 9:17am
    Watsonville , California

    What about. Using turmeric

  •  
    Submitted by BaselineFoundation on
    May 12, 2016 - 11:07am

    Turmeric does have antibacterial properties, but it is hardly the strongest anti-pathogen available. That said, you don’t want to eliminate all bacteria in the mouth—just the bad ones. Some oral bacteria are essential for good periodontal health. It’s a question of balance.

  •  
    Submitted by Jim Davis on
    May 10, 2016 - 1:48pm

    This article was written in such a way as to give credence to the idea that these bacteria are the cause of disease. Anyone well versed in alternative health care knows that bacteria can only grow where the conditions are favorable for them.
    A body that has tooth decay is severely mineral deficient, mostly calcium deficient, and it is these deficiencies that cause diseases like pancreatic cancer. It is also these deficiencies that create the conditions for bacteria that wouldn't be found in someone that was healthier.

    This kind of thinking and writting is what keeps people from realizing that they have control over the health of their own bodies. By blaming a bacteria instead it promotes the idea that we have no control, like "It isn't what I am eating or drinking or thinking that caused me to be sick, it is these nasty bacteria, just bad luck is all, there's nothing I can do about it".

  •  
    Submitted by BaselineFoundation on
    May 12, 2016 - 11:08am

    Perhaps you can read the article again. The article merely indicates that bacteria can be a contributing factor in disease. But in no way does the article imply that they are the sole cause, or that you need to be a victim of bacteria.

  •  
    Submitted by Philip Torrance on
    May 11, 2016 - 12:01am
    tucson , Arizona

    . when bacteria is associated with pancreatic cancer
    it's likely that the same diet that promotes
    risk factors for pancreatic cancer
    (obesity, diabetes, and chronic pancreatitis)
    also selects bad kinds of bacteria;
    thus, the bacteria is not causing the cancer.
    . one risk factor for chronic pancreatitis
    is high triglycerides, that can be caused by
    high fructose from high sugar.
    . sugar is notorious for causing dental problems
    undoubtedly by encouraging the wrong kind of bacteria.

  •  
    Submitted by BaselineFoundation on
    May 12, 2016 - 11:08am

    There is no question that diet affects both your ability to defend against disease and can accelerate the progression of the disease. But it doesn’t mean that outside pathogens aren’t also a factor in the onset of disease.

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