Pros and Cons of 5-HTP for Depression | Mental Health Blog

Date: 07/30/2016    Written by: Hiyaguha Cohen

Pros and Cons of 5-HTP

Pros and Cons of 5-HTP for Depression | Mental Health Blog

They sample it at Costco, promising that you’ll feel better if you take just a few doses daily. The name makes it sound like a type of car oil, but 5-HTP (short for hydroxyl L-tryptophan) actually is a chemical that the body produces as it processes the amino acid tryptophan in the foods you eat.1 It’s what the tryptophan in your milk becomes after you drink it. Once tryptophan becomes 5-HTP, it converts again to serotonin—a key neurotransmitter that supports good mood and sleep. You need naturally produced 5-HTP to maintain your sunny disposition, but if you’re stressed, it could be in short supply. In that case, you can buy 5-HTP supplements derived from the seeds of a West African shrub.2

The touted benefits of 5-HTP are many, but then again, so are the warnings about taking it. What’s the real story?

Warp Speed from Baseline Nutritionals

On the plus side, several studies have found that 5-HTP works as well as antidepressants to fend off the blues. (Of course, given the dismal performance of most antidepressants, that’s not an earth-shattering result.) Research has also found that 5-HTP has fewer side effects than its pharmaceutical counterparts, and that’s a big deal. It works within 30 minutes for most people. That’s a whole lot faster than antidepressants work, and most can tolerate it well with far fewer side effects than antidepressant users experience. It isn’t completely without side effects, though. Some complain of nausea, mild headache, vomiting, and diarrhea, and there’s even some evidence it can worsen symptoms of schizophrenia in psychotic patients.3

On the other hand, the study samples were small and to date, we’re talking about just two studies out of 30 that were run to completion. There are thousands of user testimonials, but again, real studies are lacking and most experts say more research is needed to evaluate the effects. Why only two completed studies? Because while the research was being conducted, a smattering of 5-HTP users contracted EMS, or eosinophilia-myalgia syndrome, which damages muscles and can actually be fatal.4 Some experts say the problem was caused by a single batch of 5-HTP contaminated with a poison called Peak X, others say the contamination problem still exists (although there is no evidence to that effect), and still others think the EMS may be attributed not to the contaminant but to 5-HTP itself (with, again, no actual evidence to that effect).

Only 10 patients were affected by the disease, and some advocates say avoiding 5-HTP is like avoiding strawberries altogether because a single batch had salmonella a few years ago. It was  a limited outbreak resulting from the single bad batch. Others say that we still don’t know why the outbreak happened and that it would be wise to avoid 5-HTP at all costs. Of course, many of those in the “stay away from the stuff” camp are medical professionals who recommend pharmaceutical antidepressants instead. The irony is that the pharmaceutical antidepressants have been connected to far more adverse effects than the 5-HTP supplements. In fact, an article in the British Medical Journal claims that antidepressants lead to half a million deaths worldwide annually by provoking sudden heart failure and suicide.5 Doing the math, it would seem obvious that 5-HTP is a safer bet, even given the fact that a whole lot more people take antidepressants than 5-HTP. Then again, thousands of people swear by it on Amazon.6

Still, it would be wise to exercise some caution and not exceed recommended dosage. Also, if you’re taking antidepressants already or certain other medications, you run the risk of flooding your system with too much serotonin if you also take 5-HTP, and that can lead to seizures and death. So, check for drug interactions before adding 5-HTP to your supplement regimen if you’re taking any prescription medication. And, if you have hypertension, proceed with caution. Studies show that 5-HTP constricts blood vessels, and given that vessel constriction causes hypertension in the first place, it’s not a good thing to exaggerate the effect. On the other hand, the studies finding such constriction all were conducted within test tubes, whereas studies done on actual humans found a blood-pressure lowering effect from 5-HTP.7Go figure. Even the experts are befuddled.

The thing is, even with all the cautionary notes, 5-HTP offers so many benefits besides its antidepressant properties that it’s certainly worth considering. (Remember, the side effects are far rarer and, for the most part, more benign than those that come with pharmaceuticals).

One of those other benefits is its use as a sleep aid. One study found that when combined with GABA, 5-HTP helped insomniacs to fall asleep sooner, stay asleep longer, and enjoy better quality rest.8 That may be because 5-HTP produces not only serotonin, but melatonin as well.9 It’s also been found to reduce night terrors in children. Several other studies found promising results when fibromyalgia patients took 5-HTP to reduce pain and morning stiffness.10 Because it increases serotonin, it’s also been found useful as a sleep aid, an anti-anxiety aid, and to control appetite.

Bottom line: If you want an alternative to pharmaceuticals, you might want to try 5-HTP, but make sure to buy a high-quality brand and get a formula that also contains B-6, which increases availability.

  • 1. “5-Hydroxytrytophan (5-HTP).” University of Maryland Health Center. 21 July 2016.
  • 2. 5-HTP.” WebMD. 21 July 2016.
  • 3. “5-HTP.” 21 July 2016.
  • 4. “Do Not Try 5-HTP Until You Read the Facts About it Now.” 21 July 2016.
  • 5. Parsons, Jeff. “Antidepressant drugs are immensely harmful and responsible for thousands of deaths claims leading scientist.” 13 May 2015. Mirror. 22 July 2016.
  • 6.
  • 7. Watts, Stephanie W. and Davis, Robert Patrick. “5-Hydroxtryptamine Receptors in Systemic Hypertension: an arterial focus.” 29 February 2011. Cardiovascular Therapy.” 21 July 2016.
  • 8. Shell, W. et al. “A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep.” March April 2010. American Journal of Therapy. 21 July 2016.
  • 9.
  • 10. Stevens, Cara J. “5-HTP: Side Effects and Dangers.” 14 June 2015. Healthline. 22 July 2016.

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    Submitted by Jen on
    August 17, 2016 - 2:00pm

    I took 5-HTP to help me sleep once and the next morning I felt really ill. I was shaking inside, felt scared and just dreadful. I would never touch anything again with 5-HTP.

    Submitted by Katherine on
    August 23, 2016 - 8:00pm
    marietta , Georgia

    I'm concerned about this "dismal performance of antidepressants" comment. Not all antidepressants work the same, and there is some trial and error to find THE one that works for someone. And not everyone benefits from an antidepressant. But with any medication and certainly with any over the counter and natural supplements you NEED to consult your doctor or a pharmacist. Many of the over the counter and/or natural products (even some vitamins) interact with medications people are taking. Many antibiotics do not react well with antacids, dairy, or vitamins. Many antidepressants do not react well with St. John's Wart. So you need to consult a doctor or pharmacist before taking anything, and certainly if you're already taking prescribed medications.

    Submitted by EttienneC on
    August 24, 2016 - 5:48am
    Johannesburg ,

    I've been using 5-HTP for quite a while.

    Started using it while quitting heroin addiction. It seriously helps allot with energy and staying positive.

    However, out of all the 5-HTP brands I have gotten only 1 of them that actually worked at all. And after a while the pharmacy where I usually got it at and all pharmacies in my country got new law that prohibits the sale of it without a prescription. That's so typical as pharma anti-depression meds was loosing profits because this stuff worked too well for too many people.

    I have also noticed that the longer you constantly use it the less you need it. It repairs your body in the long run. Now that I've been taking it for 2 years, I can go a long time without it.
    (Remember it will stay that way until you start to eat wrong, drink alcohol, use pharma meds, then that goes down the drain and you need it again.)

    To find out how well it works, you NEED to use it for a minimum of 6 weeks no less! Then stop, and you will notice in 24 hours the difference of not taking it. You don't really notice any difference when you start using it, that's why stopping shows you quite a big change.

    But all the natural sources of 5-htp capsules have dried up and now you get a white powder in a capsule and that stuff just does not work well at all.

    So I have found the liquid version of 5-HTP which comes directly from the plant called "African Griffonia". The best thing is it only costs a third of what the capsule brands charge now and it literally works 80% better and last twice as long.

    But be careful, like I said there's very little brands 'manufacturers' that gives you the real thing. Sad but true.
    If you can find a capsule with fine bitter brown plant matter inside then that's a win. Don't go for the no taste white powder!

    Also found a side effect with me is it increases my sex drive, which I figured is because of not being depressed. As depression pretty much kills your sex drive.
    Well that's just my experience with it.

    I've used a bunch of nasty anti-depressants and NONE of them worked except for this natural life saver.
    (I was apparently diagnosed with bi-polar disorder, but that's just something you CAN get over, not a life sentence which is a total lie.)

    I hope I encouraged someone.
    Thank so much for posting this great informative article which I'll be sharing everywhere!


    Submitted by Darren Murray on
    February 20, 2019 - 1:00am
    London, England ,

    A very nicely balanced piece of work here, which to be honest, is a rare thing on the net these days.

    From my limited neuro-chemistry knowledge base, I would suggest that even taking too much 5-htp would not cause the body to produce too much serotonin as the body will only convert as much as it requires. Of course there maybe issues other than this, which may relate to toxicity elsewhere in the body.

    If anyone is concerned about taking 5-HTP, they could of course take Tryptophan instead to ensure the body has enough to convert. Of course, as 5-HTP has a better bioavailability to convert directly to serotonin, a much higher dose of tryptophan will be required.

    On a personal level, I have taken 5-HTP as part of a fitness supplement for years in the past without any ill affect.

    Thanks for the piece.

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